پیشرفت‌ها در شیمی پروتئین و زیست‌شناسی ساختاری. جلد صد و سوم: کانال‌های یونی به عنوان اهداف درمانی. بخش الف / ویرایش شده توسط راسن دانف

The Cys-loop receptors play prominent roles in the nervous system. They include γ-aminobutyric acid type A receptors, nicotinic acetylcholine receptors, 5-hydroxytryptamine type-3 receptors, and glycine receptors. Proteostasis represents an optimal state of the cellular proteome in normal physiology. The proteostasis network regulates the folding, assembly, degradation, and trafficking of the Cys-loop receptors, ensuring their efficient functional cell surface expressions. Here, we summarize current advances about the protein biogenesis process of the Cys-loop receptors. Because operating on individual biogenesis steps influences the receptor cell surface level, manipulating the proteostasis network components can regulate the function of the receptors, representing an emerging therapeutic strategy for corresponding channelopathies.

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

• Provides cutting-edge developments in protein chemistry and structural biology
• Discusses the use of ion channels as therapeutic targets
• Chapters are written by authorities in their field
• Targeted to a wide audience of researchers, specialists, and students

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students This volume is the second part ofïÅ1⁄2the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, ïÅ1⁄2brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics