Advances in Nutritional Research Volume 10: Immunological Properties of Milk (Advances in Nutritional Research (10))

This volume of Advances in Nutritional Research focuses on colostrum and milk as agents of defense against infection both for the suckling offspring and for the lactating mammary gland. The scope of the volume includes positive and negative influences of the consumption of mother's milk on the risk of infec­ tion, immunobiological roles of individual milk components, activities of milk and its components in promoting development of neonatal immunocompetence, the potential of milk and its components as therapeutic agents and as functional foods that support immune competence, and external influences that determine the immunological activity of milk. The volume is intended to provide a critical assessment of the limits of available information pertaining to humans and animals, together with authoritative comment regarding newer directions and unproven ideas. Part I provides a foundation for the volume. Readers unfamiliar with immunology will find, in Chapter 1, a selective outline of the anatomy and ontogeny of the mammalian immune system and of the types and regulation of immune defenses in mammals. Some emphasis is given to the place of the mammary gland within the common mucosal defense system, and to important species peculiarities in this regard. Chapter 2 is an authoritative and forward­ looking perspective on the development of knowledge pertaining to the immuno­ biology of milk as a fluid with both anti-infectious and anti-inflammatory roles. The chapter poses the provocative possibility of a tolerogenic role for milk. Overview of the mammalian immune system / A.J. Husband The immunological system in human milk: the past, a pathway to the future / Armond S. Goldman Immunological activities associated with milk / Shannon L. Kelleher, Bo Lönnerdal Breast milk and the risk of opportunistic infection in infancy in industrialized and non-industrialized settings / Patrick F.W. Chien, Peter W. Howie Breast milk transmission of viral disease / E. Richard Stiehm, Margaret A. Keller Breast milk decreases the risk of neonatal necrotizing enterocolitis / Ann M. Kosloske The protective properties of milk and colostrum in non-human species / Ian Tizard Mammary gland defense: the role of colostrum, milk and involution secretion / Catherine M. Fetherston, Chee Seong Lee, and Peter E. Hartmann Colostrum and milk in the treatment of disease / Saeed Hosseini ... [et al.] The role of human milk secretory IgA in protecting infants from bacterial enteritis / Marita Noguera-Obenze, Thomas G. Cleary Chemistry of milk mucins and their anti-microbial action / H. Schroten Antimicrobial actions of lactoferrin / Roberta Chierici The antimicrobial function of milk lipids / Charles E. Isaacs The antimicrobial and immunomodulating actions of milk leukocytes / Gerd Riedel-Caspari Maturation of immunocompetence in breast-fed vs. formula-fed infants U.I. Dahlgren, L. Å. Hanson, E. Telemo Milk components with immunomodulatory potential / Suzanne M. Filteau Dietary whey proteins and immunocompetence in the post-weaning stages of life / C. W. Wong Maternal modulation of specific and non-specific immune components of colostrum and mature milk / Peter E. Hartmann, Mark D. Cregan, Leon R. Mitoulas Milk banking: the influence of storage procedures and subsequent processing on immunologic components of human milk / Ruth A. Lawrence. Front Matter....Pages i-xxix Front Matter....Pages 1-1 Overview of the Mammalian Immune System....Pages 3-14 The Immunological System in Human Milk: The Past—A Pathway to the Future....Pages 15-37 Immunological Activities Associated with Milk....Pages 39-65 Front Matter....Pages 67-67 Breast Milk and the Risk of Opportunistic Infection in Infancy in Industrialized and Non-Industrialized Settings....Pages 69-104 Breast Milk Transmission of Viral Disease....Pages 105-122 Breast Milk Decreases the Risk of Neonatal Necrotizing Enterocolitis....Pages 123-137 The Protective Properties of Milk and Colostrum in Non-Human Species....Pages 139-166 Mammary Gland Defense: The Role of Colostrum, Milk and Involution Secretion....Pages 167-198 Front Matter....Pages 199-199 Colostrum and Milk in the Treatment of Disease....Pages 201-212 The Role of Human Milk Secretory IgA in Protecting Infants from Bacterial Enteritis....Pages 213-229 Chemistry of Milk Mucins and Their Anti-Microbial Action....Pages 231-245 Antimicrobial Actions of Lactoferrin....Pages 247-269 The Antimicrobial Function of Milk Lipids....Pages 271-285 The Antimicrobial and Immunomodulating Actions of Milk Leukocytes....Pages 287-307 Front Matter....Pages 309-309 Maturation of Immunocompetence in Breast-Fed vs. Formula-Fed Infants....Pages 311-325 Milk Components with Immunomodulatory Potential....Pages 327-350 Dietary Whey Proteins and Immunocompetence in the Post-Weaning Stages of Life....Pages 351-362 Front Matter....Pages 363-363 Maternal Modulation of Specific and Non-Specific Immune Components of Colostrum and Mature Milk....Pages 365-387 Milk Banking: The Influence of Storage Procedures and Subsequent Processing on Immunologic Components of Human Milk....Pages 389-404 Back Matter....Pages 405-410 This volume will treat the various aspects of milk with regard to allergies, immunology, toxicology, and general health and will reflect the current research in these areas. It will be volume 10 in the series. This volume treats the various aspects of milk with regard to allergies, immunology, toxicology, and general health, reflecting developments and research in these areas. This volume examines various aspects of milk, with regard to allergies, immunology, toxicology, and general health, reflecting developments and research in these areas