Advances in Nanotheranostics II : Cancer Theranostic Nanomedicine

This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China. Front Matter....Pages i-xi Front Matter....Pages 1-1 Design of Magnetic Nanoparticles for MRI-Based Theranostics....Pages 3-37 Controlled Synthesis and Surface Modification of Magnetic Nanoparticles with High Performance for Cancer Theranostics Combining Targeted MR Imaging and Hyperthermia....Pages 39-73 Molecular Imaging of Tumor Angiogenesis with Magnetic Nanoprobes....Pages 75-104 Front Matter....Pages 105-105 Multifunctional Ultrasound Contrast Agents Integrating Targeted Imaging and Therapy....Pages 107-151 Next-Generation Ultrasonic Theranostic Agents for Molecular Imaging and Therapy: Design, Preparation, and Biomedical Application....Pages 153-188 Multifunctional Hollow Mesoporous Silica Nanoparticles for MR/US Imaging-Guided Tumor Therapy....Pages 189-222 Front Matter....Pages 223-223 Multifunctional Nanoprobes for Multimodality Targeted Imaging and Therapy of Gastric Cancer....Pages 225-271 Functional Nanoparticles for Molecular Imaging-Guided Gene Delivery and Therapy....Pages 273-305 Multifunctional Mesoporous/Hollow Silica for Cancer Nanotheranostics....Pages 307-354 Multimodal Micelles for Theranostic Nanomedicine....Pages 355-381 This book highlights the recent advances in nanotheranostics from basic research to potential applications, and discusses the modular design and engineering of multiplex nanoparticles including gold nanostructures, luminescent nanoparticles, dendrimers and liposomes.