Advances in Molecular and Cell Biology, Vol. 32: Molecular Insights Into Ion Channel Biology in Health and Disease

Covers a broad spectrum of data emerging from families of ion channels and offers new new viewpoints on the important classes of these channels. Highlights instances where the function and dysfunction of channel molecules have furthered understanding of the physiology and pathophysiology of cells tissues and organs. Abundant illustrations. For researchers. Content: Contents Pages v-vi Preface Pages vii-ix ATP-sensitive potassium channels and insulin secretion diseases Review Article Pages 1-14 C.G. Nichols, S.-L. Shyng, B. Marshall, J.C. Koster The biology of voltage-gatedsodium channels Review Article Pages 15-50 John H Caldwell, S.Rock Levinson Towards a natural history of calcium-activated potassium channels Review Article Pages 51-71 David P. McCobb Cystic fibrosis transmembrane conductance regulator Review Article Pages 73-94 J.W Hanrahan Molecular insights into acetylcholine receptor structure and function revealed by mutations causing congenital myasthenic syndromes Review Article Pages 95-119 Steven M. Sine, Andrew G. Engel, Hai-Long Wang, Kinji Ohno Store-operated calcium channels: properties, functions and the search for a molecular mechanism Review Article Pages 121-140 Murali Prakriya, Richard S. Lewis Neurodegenerative disease and the neuroimmunobiology of glutamate receptors Review Article Pages 141-159 Lorise C. Gahring, Noel G. Carlson, Erin L. Meyer, Emily L. Days, Scott W. Rogers Gap junction mutations in human disease Review Article Pages 161-187 Matthew G Hopperstad, Miduturu Srinivas, Alfredo Fort, David C Spray Molecular physiology and pathophysiology of ClC-type chloride channels Review Article Pages 189-217 Christoph Fahlke Steroid modulation of GABA A receptors:from molecular mechanisms to CNS roles in reproduction, dysfunction and drug abuse Review Article Pages 219-250 Leslie P. Henderson, Juan Carlos Jorge Cyclic nucleotide-gated channels: multiple isoforms, multiple roles Review Article Pages 251-267 Marie-Christine Broillet, Stuart Firestein Nicotinic acetylcholine receptors in the nervous system Review Article Pages 269-302 Joseph P Margiotta, Phyllis C Pugh The ENaC/Deg family of cation channels Review Article Pages 303-329 Sylvie Coscoy, Pascal Barbry Vanilloid receptor 1 (VR1): an integrator of noxious and inflammatory stimuli ∗ Review Article Pages 331-350 Stuart Bevan, Alison J Reeve Novel roles for aquaporins as gated ion channels Review Article Pages 351-379 Andrea J. Yool, W.Daniel Stamer Molecular and functional insights into voltage-gated calcium channels Review Article Pages 381-406 Anthony Stea, Terrance P. Snutch Ion channels and sperm function Review Article Pages 407-431 Ricardo Felix, Ignacio López-González, Carlos Muñoz-Garay, Alberto Darszon Ion channels on intracellular organelles Review Article Pages 433-458 Leonard K. Kaczmarek, Elizabeth A. Jonas Colour plates Pages 459-469 Contributors Pages 471-475 Index Pages 477-785