Advances in Mitochondrial Medicine (Advances in Experimental Medicine and Biology Book 942)

Mitochondria Are Far More Than The Powerhouse Of The Cell As They Have Classically Been Described. In Fact, Mitochondria Biological Activities Have Progressively Expanded To Include Not Only Various Bioenergetic Processes But Also Important Biosynthetic Pathways, Calcium Homeostasis And Thermogenesis, Cell Death By Apoptosis, Several Different Signal Transduction Pathways Mainly Related To Redox Control Of Gene Expression And So On. This Functional And Structural Complexity May Undergo Important Derangements So To Justify The Definition Of Mitochondrial Medicine, Which Should Include All The Clinical Consequences Of Congenital Or Acquired Mitochondrial Dysfunctions. There Are Actually A Growing Number Of Studies Which Assign A Significant Pathogenic Role To Damaged Mitochondria In Different Diseases: Ischemia/reperfusion Injury, Neurodegenerative Diseases, Cancer With Its Dramatic Sequelae (i.e, Metastasis), Metabolic Syndrome, Hyperlipidemias, Just To Mention A Few Of The Most Important Pathologies. In This Context, A Further Aspect That Should Not Be Disregarded Is The Interaction Of Pharmacological Agents With Mitochondria, Not Only In Regard Of The Toxicological Aspects But, Above All, Of The Potential Therapeutic Applications. In Fact, It Is Interesting To Note That, While The Properties Of Different So-called Mitoxicants Are Well-known, The Subtle Linkages Between Drugs And Mitochondria Is Still In Need Of A Real Pharmacological And Therapeutic Control At The Clinical Level. This Lack Of Consideration Can Often Lead To An Underestimation Of Unwanted Toxic Effects But Also Of Desirable Therapeutic Activities. A Reevaluation Of The Potential Clinical Role Of Mitochondria Could Give A New Light On Some Yet Obscure Aspects Of Human Pathophysiology. Part 1. Physiology And Structure Of Mitochondria / The Oxidative Phosphorylation System In Mammalian Mitochondria / Sergio Papa, Pietro Luca Martino, Giuseppe Capitanio, Antonio Gaballo And Domenico De Rasmo, Et Al. -- Physiology And Pathophysiology Of Mitochondrial Dna / Hongzhi Li, Danhui Liu, Jianxin Lu And Yidong Bai -- Mitochondrial Ca2+ As A Key Regulator Of Mitochondrial Activities / Tito Calì, Denis Ottolini And Marisa Brini -- Mitochondria And Nitric Oxide: Chemistry And Pathophysiology / Paolo Sarti, Marzia Arese, Elena Forte, Alessandro Giuffrè And Daniela Mastronicola -- Mitochondria And Reactive Oxygen Species. Which Role In Physiology And Pathology? / Giorgio Lenaz -- Uncoupling Proteins: Molecular, Functional, Regulatory, Physiological And Pathological Aspects / Francis E. Sluse -- The Mitochondrial Pathways Of Apoptosis / Jérome Estaquier, François Vallette, Jean-luc Vayssiere And Bernard Mignotte -- Part 2. Mitochondria And Disease / Inherited Mitochondrial Disorders / Josef Finsterer -- Role Of Mitochondrial Function In Insulin Resistance / Myrte Brands, Arthur J. Verhoeven And Mireille J. Serlie -- Mitochondria And Diabetes. An Intriguing Pathogenetic Role / Philip Newsholme, Celine Gaudel And Maurico Krause -- Mitochondria And Heart Disease / Elinor J. Griffiths -- Mitochondria In Neurodegeneration / E Lezi And Russell H. Swerdlow -- Mitochondria And Cancer: A Growing Role In Apoptosis, Cancer Cell Metabolism And Dedifferentiation / Roberto Scatena -- Part 3. Mitochondria And Aging / Mitochondria And Aging / Hsin-chen Lee And Yau-huei Wei -- Mitochondria And Drugs / Roberto Scatena -- Iatrogenic Mitochondriopathies: A Recent Lesson From Nucleoside/nucleotide Reverse Transcriptase Inhibitors / George P. H. Leung -- Dysfunction Of Mitochondrial Respiratory Chain Complex I In Neurological Disorders: Genetics And Pathogenetic Mechanisms / Vittoria Petruzzella, Anna Maria Sardanelli, Salvatore Scacco, Damiano Panelli And Francesco Papa, Et Al. -- Anthracyclines And Mitochondria / Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini, Giuseppe Ettore Martorana And Bruno Giardina -- Mitochondrial Proteomic Approaches For New Potential Diagnostic And Prognostic Biomarkers In Cancer / Patrizia Bottoni, Bruno Giardina, Alessandro Pontoglio, Salvatore Scarà And Roberto Scatena -- Mitochondria In Anthropology And Forensic Medicine / Tomasz Grzybowski And Urszula Rogalla. Roberto Scatena, Patrizia Bottoni, Bruno Giardina, Editors. Includes Index. Physiology and structure of mitochondria. The oxidative phosphorylation system in mammalian mitochondria -- Sergio Papa ... [et al.] Physiology and pathophysiology of mitochondrial DNA -- Hongzhi Li ... [et al.] Mitochondrial Ca2+ as a key regulator of mitochondrial activities -- Tito Calì, Denis Ottolini, and Marisa Brini Mitochondria and nitric oxide : chemistry and pathophysiology -- Paolo Sarti ... [et al.] Mitochondria and reactive oxygen species : which role in physiology and pathology? -- Giorgio Lenaz Uncoupling proteins : molecular, functional, regulatory, physiological, and pathological aspects -- Francis E. Sluse The mitochondrial pathways of apoptosis -- Jérome Estaquier ... [et al.]. Mitochondria and disease. Inherited mitochondrial disorders -- Josef Finsterer Role of mitochondrial function in insulin resistance -- Myrte Brands, Arthur J. Verhoeven, and Mireille J. Serlie Mitochondria and diabetes : an intriguing pathogenetic role -- Philip Newsholme, Celine Gaudel, and Maurico Krause Mitochondria and heart disease -- Elinor J. Griffiths Mitochondria in neurodegeneration -- Lezi E and Russell H. Swerdlow Mitochondria and cancer : a growing role in apoptosis, cancer cell metabolism, and dedifferentiation -- Roberto Scatena. Mitochondria, aging, and pharmacotoxicological aspects. Mitochondria and aging -- Hsin-Chen Lee and Yau-Huei Wei Mitochondria and drugs -- Roberto Scatena Iatrogenic mitochondriopathies : a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors -- George P.H. Leung Dysfunction of mitochondrial respiratory chain complex I in neurological disorders : genetics and pathogenetic mechanisms -- Vittoria Petruzzella ... [et al.] Anthracyclines and mitochondria -- Alvaro Mordente ... [et al.]. Applications of mitochondrial science. Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer -- Patrizia Bottoni ... [et al.] Mitochondria in anthropology and forensic medicine -- Tomasz Grzybowski and Urszula Rogalla. Front Matter....Pages i-xii Front Matter....Pages 1-1 The Oxidative Phosphorylation System in Mammalian Mitochondria....Pages 3-37 Physiology and Pathophysiology of Mitochondrial DNA....Pages 39-51 Mitochondrial Ca 2+ as a Key Regulator of Mitochondrial Activities....Pages 53-73 Mitochondria and Nitric Oxide: Chemistry and Pathophysiology....Pages 75-92 Mitochondria and Reactive Oxygen Species. Which Role in Physiology and Pathology?....Pages 93-136 Uncoupling Proteins: Molecular, Functional, Regulatory, Physiological and Pathological Aspects....Pages 137-156 The Mitochondrial Pathways of Apoptosis....Pages 157-183 Front Matter....Pages 185-185 Inherited Mitochondrial Disorders....Pages 187-213 Role of Mitochondrial Function in Insulin Resistance....Pages 215-234 Mitochondria and Diabetes. An Intriguing Pathogenetic Role....Pages 235-247 Mitochondria and Heart Disease....Pages 249-267 Mitochondria in Neurodegeneration....Pages 269-286 Mitochondria and Cancer: A Growing Role in Apoptosis, Cancer Cell Metabolism and Dedifferentiation....Pages 287-308 Front Matter....Pages 309-309 Mitochondria and Aging....Pages 311-327 Mitochondria and Drugs....Pages 329-346 Iatrogenic Mitochondriopathies: A Recent Lesson from Nucleoside/Nucleotide Reverse Transcriptase Inhibitors....Pages 347-369 Dysfunction of Mitochondrial Respiratory Chain Complex I in Neurological Disorders: Genetics and Pathogenetic Mechanisms....Pages 371-384 Anthracyclines and Mitochondria....Pages 385-419 Front Matter....Pages 421-421 Mitochondrial Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers in Cancer....Pages 423-440 Mitochondria in Anthropology and Forensic Medicine....Pages 441-453 Back Matter....Pages 455-461