Advances in metabolic mapping techniques for brain imaging of behavioral and learning functions : proceedings of the NATO Advanced Research Workshop on Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions, Austin

In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities. Front Matter....Pages i-xxiv Front Matter....Pages i-xxiv Imaging Techniques In Studies Of Neural Functions....Pages 1-37 Brain Imaging of Auditory Learning Functions in Rats: Studies with Fluorodeoxyglucose Autoradiography and Cytochrome Oxidase Histochemistry....Pages 39-109 Mapping Sensorimotor Pathways in Rat Brain Using 2-Deoxyglucose Autoradiography and C-Fos Immunocytochemistry....Pages 111-124 Brain Metabolic Mapping and Behaviour: Assessing the Effects of Early Developmental Experiences in Adult Animals....Pages 125-149 High Resolution Autoradiographic Imaging of Brain Activity Patterns with 2-Deoxyglucose: Regional Topographic and Cellular Analysis....Pages 151-172 Metabolic Mapping in the Hippocampus . Patterns of ( 14 C)2-Deoxyglucose Uptake Within Different Fields of the Hippocampal Slice....Pages 173-188 Covariance Analysis of Functional Interactions in the Brain Using Metabolic and Blood Flow Data....Pages 189-217 The Application of Structural Modeling to Metabolic Mapping of Functional Neural Systems....Pages 219-255 Front Matter....Pages 257-257 A 2-DG Analysis Of The Effects Of Monocular Deprivation On The Rat Visual System....Pages 259-279 Development of Sound Representation in the Auditory Cortex of Tree Shrews (Tupaia Belangeri): A [ 14 C]-2-Dg Study....Pages 281-297 Integration of Circadian and Visual Function in Mammals and Birds: Brain Imaging and the Role of Melatonin in Biological Clock Regulation....Pages 299-317 Functional Correlates of Acute Prolonged Pain in the Rat Central Nervous System: 2-DG Studies....Pages 319-342 Brain Systems Involved in Depressed Behaviors: Corroboration From Different Metabolic Mapping Studies.....Pages 343-366 2-DG and Neuroethology: Metabolic Mapping of Brain Activity During Species-Typical Sexual and Aggressive Behaviors....Pages 367-387 Investigations into Time-Dependent Metabolic Changes During Memory Processing in the Mouse Brain Using ( 14 C) Deoxyglucose and ( 14 C)-Glucose.....Pages 389-407 Localization of Learning-related Metabolical Changes in Brain Structures of Common Toads: a 2-DG-study....Pages 409-445 Learning-Related Plasticity of Gerbil Auditory Cortex: Feature Maps Versus Meaning Maps....Pages 447-474 Front Matter....Pages 475-475 Discussions on Advances in Metabolic Mapping Techniques....Pages 477-493 Discussions on Brain Imaging of Behavioral Functions....Pages 494-508 Discussions on Brain Imaging of Learning Functions....Pages 509-522 Back Matter....Pages 523-527 "In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities"--Font no determinada Proceedings of the NATO Advanced Research Workshop, Austin, Texas, U.S.A., November 7-9, 1991