Advances in Inorganic Chemistry. Volume 38: Iron-Sulphur Proteins

Dedicated to Professor Helmut Beinert, this volume contains contributions from some of the foremost workers in the field of iron-sulfur proteins. This important class of metalloproteins contains clusters of iron and sulfur atoms, and was originally discovered as electron transfer agents involved in the bioenergetics of animals, plants, and bacteria. Since Beinert's pioneering work beginning nearly 40 years ago, iron-sulfur proteins have been the subject of intense investigation as this book demonstrates. Recent years have seen the discovery of (3Fe-4S) clusters, cluster interconversions, the formation of mixed-metal clusters, and direct participation of clusters in catalysis. Studies of molecular evolution of these proteins have revealed unexpected sequence homolgies, and most recently, the apparent involvement of iron-sulfur proteins in post-transciptional regulatory mechanisms Content: Advisory Board Page ii Edited By Page iii Copyright page Page iv Helmut Beinert Pages ix-xi Trinuclear Cuboidal and Heterometallic Cubane-Type Iron–Sulfur Clusters: New Structural and Reactivity Themes in Chemistry and Biology Original Research Article Pages 1-71 R.H. Holm Replacement Of Sulfur By Selenium In Iron—Sulfur Proteins Original Research Article Pages 73-115 Jacques Meyer, Jean-Marc Moulis, Jacques Gaillard, Marc Lutz Dynamic Electrochemistry of Iron—Sulfur Proteins Original Research Article Pages 117-163 Fraser A. Armstrong EPR Spectroscopy of Iron—Sulfur Proteins Original Research Article Pages 165-222 Wilfred R. Hagen Structural and Functional Diversity of Ferredoxins and Related Proteins Original Research Article Pages 223-280 Hiroshi Matsubara, Kazuhiko Saeki Iron—Sulfur Clusters in Enzymes: Themes and Variations Original Research Article Pages 281-322 Richard Cammack Aconitase: An Iron—Sulfur Enzyme Original Research Article Pages 323-339 Mary Claire Kennedy, C. David Stout Novel Iron—Sulfur Centers in Metalloenzymes and Redox Proteins from Extremely Thermophilic Bacteria Original Research Article Pages 341-396 Michael W.W. Adams Evolution of Hydrogenase Genes Original Research Article Pages 397-422 Gerrit Voordouw Density-Functional Theory of Spin Polarization and Spin Coupling in Iron—Sulfur Clusters Original Research Article Pages 423-458,458a,458b,459-470 Louis Noodleman, David A. Case Index Pages 471-483 Contents of Recent Volumes Pages 484-487 This volume in a series on inorganic chemistry deals, among a number of topics, with drug design, inorganic pharmacology, the extraction of metals from ores by means of bacteria, solid-state bio-inorganic chemistry and the mechanisms and models of biomineralization. Since Professor Helmut Beinert's pioneering work 40 years ago, iron-sulfur proteins have been the subject of intense investigation. This volume contains contributions from some of the foremost workers in this field.