Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium (Advances in Experimental Medicine and Biology Book 814)

"To celebrate the Center for Perinatal Biology's 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease"--Publisher's description Front Matter....Pages i-xx “Surprised by Joy”*: Four Decades of Contributions to Developmental Physiology....Pages 1-4 sGC-cGMP Signaling: Target for Anticancer Therapy....Pages 5-13 Lawrence D. Longo: From Chronic Fetal Hypoxia to Proteomic Predictors of Fetal Distress Syndrome – A Life Devoted to Research and Mentoring Based on Virtue-Ethics....Pages 15-26 Pregnancy Programming and Preeclampsia: Identifying a Human Endothelial Model to Study Pregnancy-Adapted Endothelial Function and Endothelial Adaptive Failure in Preeclamptic Subjects....Pages 27-47 Regulation of Amniotic Fluid Volume: Evolving Concepts....Pages 49-68 Gestational Diabetes, Preeclampsia and Cytokine Release: Similarities and Differences in Endothelial Cell Function....Pages 69-75 Heart Disease Link to Fetal Hypoxia and Oxidative Stress....Pages 77-87 Fetal Breathing Movements and Changes at Birth....Pages 89-101 From Fetal Physiology to Gene Therapy: It All Started in Loma Linda....Pages 103-108 30 + Years of Exercise in Pregnancy....Pages 109-116 Gap Junction Regulation of Vascular Tone: Implications of Modulatory Intercellular Communication During Gestation....Pages 117-132 Effect of Preeclampsia on Placental Function: Influence of Sexual Dimorphism, microRNA’s and Mitochondria....Pages 133-146 Altitude, Attitude and Adaptation....Pages 147-157 The Separation of Sexual Activity and Reproduction in Human Social Evolution....Pages 159-167 The Influence of Growth Hormone on Bone and Adipose Programming....Pages 169-176 The Fetal Cerebral Circulation: Three Decades of Exploration by the LLU Center for Perinatal Biology....Pages 177-191 Placental Vascular Defects in Compromised Pregnancies: Effects of Assisted Reproductive Technologies and Other Maternal Stressors....Pages 193-204 How to Build a Healthy Heart from Scratch....Pages 205-216 Estrogen in the Fetus....Pages 217-228 Calcitonin Gene Related Family Peptides: Importance in Normal Placental and Fetal Development....Pages 229-240 Back Matter....Pages 241-245