Advances in Experimental Medicine and Biology, Volume 646: Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond

Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike. Recent research has suggested that obesity has its origins in early life and that early diet can programme a developing fetus’ and young infant’s future susceptibility to obesity. This volume contains recent findings presented at the International Conference on Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond - a satellite meeting of the 15th European Congress on Obesity, held in Budapest in April 2007. Basic scientific research, data from epidemiological studies and clinical trial results were all presented during the programme. This volume includes articles discussing the evidence for an effect of early nutrition programming on later obesity and cardiovascular risk; the growing evidence for an intergenerational cycle of obesity; the role of maternal leptin in programming appetite; possible cellular mechanisms for altered energy balance, including mitochondrial programming and the effects of regulators of metabolism; and how epigenetic changes might be the fundamental underlying mechanism explaining programming effects. Consumer understanding of the concept of early nutrition programming and the extent to which early nutrition programming is taken into account in infant feeding policies are also discussed. Front Matter....Pages i-ix Challenges and Novel Approaches in the Epidemiological Study of Early Life Influences on Later Disease....Pages 1-14 Infant Feeding and Later Obesity Risk....Pages 15-29 Developmental Origins of Osteoporosis: The Role of Maternal Nutrition....Pages 31-39 Does Having Been Breastfed in Infancy Influence Lipid Profile in Later Life?: A Review of the Literature....Pages 41-50 The Early Origins of Atherosclerosis....Pages 51-58 Do LCPUFAs Influence Cardiovascular Function in Early Childhood?....Pages 59-63 Effects of Supplementing LCPUFA to the Diet of Pregnant Women: Data from RCT....Pages 65-69 The Early Origins of Later Obesity: Pathways and Mechanisms....Pages 71-81 Developmental Origins of Obesity: Programming of Food Intake or Physical Activity?....Pages 83-93 Nutrient–Gene Interactions in Early Life Programming: Leptin in Breast Milk Prevents Obesity Later on in Life....Pages 95-104 Early Nutrition and Later Obesity: Animal Models Provide Insights into Mechanisms....Pages 105-112 Tissue Specific Adaptations to Nutrient Supply: More than Just Epigenetics?....Pages 113-118 Epigenetics – Potential Contribution to Fetal Programming....Pages 119-123 Programming of Impaired Insulin Secretion Versus Sensitivity: Cause or Effect?....Pages 125-131 PGC-1β: A Co-activator That Sets the Tone for Both Basal and Stress-Stimulated Mitochondrial Activity....Pages 133-139 Pharmacological and Gene Modification-Based Models for Studying the Impact of Perinatal Metabolic Disturbances in Adult Life....Pages 141-148 Adipose Tissue–Muscle Interactions and the Metabolic Effects of n-3 LCPUFA – Implications for Programming Effects of Early Diet ....Pages 149-157 Trans Isomeric and LCPUFA Are Inversely Correlated in Erythrocyte Membrane Lipids at Mid-gestation....Pages 159-163 Early Growth and Body Composition in Infancy....Pages 165-168 Obesity Related Programming Statements in Infant Feeding Policies in Five European Countries....Pages 169-173 Obesity Related Programming Statements in Materials on Infant Feeding Aimed at Parents in Five European Countries....Pages 175-181 Infant Feeding and the Concept of Early Nutrition Programming: A Comparison of Qualitative Data from Four European Countries....Pages 183-187 What is the EARNEST Dissemination and Exploitation Consensus Panel (DECP)?....Pages 189-194 Back Matter....Pages 195-196 Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike. Recent research has suggested that obesity has its origins in early life and that early diet can programme a developing fetus and young infant s future susceptibility to obesity. This volume contains recent findings presented at the International Conference on Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond - a satellite meeting of the 15th European Congress on Obesity, held in Budapest in April 2007. Basic scientific research, data from epidemiological studies and clinical trial results were all presented during the programme. This volume includes articles discussing the evidence for an effect of early nutrition programming on later obesity and cardiovascular risk; the growing evidence for an intergenerational cycle of obesity; the role of maternal leptin in programming appetite; possible cellular mechanisms for altered energy balance, including mitochondrial programming and the effects of regulators of metabolism; and how epigenetic changes might be the fundamental underlying mechanism explaining programming effects. Consumer understanding of the concept of early nutrition programming and the extent to which early nutrition programming is taken into account in infant feeding policies are also discussed. "Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike. Recent research has suggested that obesity has its origins in early life and that early diet can programme a developing fetus' and young infant's future susceptibility to obesity. This volume contains recent findings presented at the International Conference on 'Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond' -- a satellite meeting of the 15th European Congress on Obesity, held in Budapest in April 2007. Basic scientific research, data from epidemiological studies and clinical trial results were all presented during the programme. This volume includes articles discussing the evidence for an effect of early nutrition programming on later obesity and cardiovascular risk; the growing evidence for an intergenerational cycle of obesity; the role of maternal leptin in programming appetite; possible cellular mechanisms for altered energy balance, including mitochondrial programming and the effects of regulators of metabolism; and how epigenetic changes might be the fundamental underlying mechanism explaining programming effects"--Provided by publisher Berthold Koletzko ... [et Al.], Editors. Contributions Based On Presentations And Discussions At A European Commission Supported Scientific Conference Held On 2-3 July 2004 At Paris, France. Includes Bibliographical References And Index.