Advances in Experimental Medicine and Biology, Volume 631: Bacterial Signal Transduction: Networks and Drug Targets

This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs. This Fascinating Book Encourages Many Microbiologists And Students To Enter The New World Of Signal Transduction In Microbiology. Over The Past Decade, A Vast Amount Of Exciting New Information On The Signal Transduction Pathway In Bacteria Has Been Brought To Light. Reports On These Developments Have Been Put Together In This Book. The Aim Of This Book Is To Provide An Incentive For Graduate Students, Academic Scientists, And Researchers In The Pharmaceutical Industry To Further Elucidate The Tcs Networks And Apply Them In The Search For Novel Drugs. Introduction To Bacterial Signal Transduction Networks / Y. Eguchi And R. Utsumi -- Phoq/phop Regulatory Network Of Salmonella Enterica / A. Kato And E.a. Groisman -- Structural Basis Of The Signal Transduction In The Two-component System / S. Yamada And Y. Shiro -- Two-component Network And The General Stress Sigma Factor Rpos In Escherichia Coli / R. Hengge -- Small Rnas Controlled By Two-component Systems / C. Valverde And D. Haas -- Two-component Signaling And Gram Negative Envelope Stress Response Systems / D.m. Macritchie ... [et Al.] -- Dual Regulation With Ser/thr Kinase Cascade And A His/asp Tcs In Myxococcus Xanthus / S. Inouye And H. Nariya -- Two-component Signaling Systems And Cell Cycle Control In Caulobacter Crescentus / E.b. Purcell, C.c. Boutte, And S. Crosson -- Regb/rega, A Global Redox-responding Two-component System / J. Wu And C.e. Bauer -- Bvgs/bvga Phosphorelay System Of Pathogenic Bordetellae: Structure, Function And Evolution / D. Beier And R. Gross -- Capturing The Vira/virg Tcs Of Agrobacterium Tumefaciens / Y.-h. Lin ... [et Al.] -- Quorum Sensing And Biofilm Formation By Streptococcus Mutans / D. Senadheera And D.g. Cvitkovitch -- Roles Of Two-component Systems In Virulence Of Pathogenic Escherichia Coli And Shigell Spp. / T. Tobe -- Vancomycin Resistance Vans/vanr Two-component Systems / H.-j. Hong, H.i. Hutchings And M.j. Buttner -- Tearing Down The Wall: Peptidoglycan Metabolism And The Walk/walr (yycg/yycf) Essential Two-component System / S. Dubrac And T. Msadek -- Inhibitors Targeting Two-component Signal Transduction / T. Watanabe ... [et Al.]. Edited By Ryutaro Utsumi. Includes Bibliographical References And Index. Front Matter....Pages i-xvii Introduction to Bacterial Signal Transduction Networks....Pages 1-6 The PhoQ/PhoP Regulatory Network of Salmonella enterica ....Pages 7-21 Structural Basis of the Signal Transduction in the Two-Component System....Pages 22-39 The Two-Component Network and the General Stress Sigma Factor RpoS (σ S ) in Escherichia coli ....Pages 40-53 Small RNAs Controlled by Two-Component Systems....Pages 54-79 Two-Component Signaling and Gram Negative Envelope Stress Response Systems....Pages 80-110 Dual Regulation with Ser/Thr Kinase Cascade and a His/Asp TCS in Myxococcus xanthus ....Pages 111-121 Two-Component Signaling Systems and Cell Cycle Control in Caulobacter crescentus ....Pages 122-130 RegB/RegA, A Global Redox-Responding Two-Component System....Pages 131-148 The BvgS/BvgA Phosphorelay System of Pathogenic Bordetellae ....Pages 149-160 Capturing the VirA/VirG TCS of Agrobacterium tumefaciens ....Pages 161-177 Quorum Sensing and Biofilm Formation by Streptococcus mutans ....Pages 178-188 The Roles of Two-Component Systems in Virulence of Pathogenic Escherichia coli and Shigella spp.....Pages 189-199 Vancomycin Resistance VanS/VanR Two-Component Systems....Pages 200-213 Tearing Down the Wall: Peptidoglycan Metabolism and the WalK/WalR (YycG/YycF) Essential Two-Component System....Pages 214-228 Inhibitors Targeting Two-Component Signal Transduction....Pages 229-236 Back Matter....Pages 237-242