Advances in DNA Repair in Cancer Therapy (Cancer Drug Discovery and Development Book 72)

A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.​ Repair Of Dna Interstrand Cross-links Produced By Cancer Chemotherapeutic Drugs / Anderson T. Wang, Peter J. Mchugh -- Dna-pk, A Pharmacological Target In Cancer Chemotherapy And Radiotherapy? / Bernard Salles D.v.m., Ph.d. -- Growth Factor Receptor Signaling, Dna Damage Response, And Cancer Cell Susceptibility To Chemotherapy And Relapses / Moulay Alaoui-jamali, Amine Saad, Gerald Batist -- The Relationship Between Dna-repair Genes, Cellular Radiosensitivity, And The Response Of Tumors And Normal Tissues To Radiotherapy / David Murray, Matthew Parliament -- Important Roles Of Ercc1 In Dna Repair And Targeted Therapy / Jennifer J. Hu, Joseph De La Garza -- The Role Of Brca1 And Brca2 In Anticancer Drug Therapy / Andrew Y. Shuen, Jorge S. Reis-filho -- Dna-pk In Cll Chemotherapy / L. Amrein, D. Davidson, R. Aloyz, L. Panasci -- Poly(adp) Ribose Polymerase At The Interface Of Dna Damage Signaling And Dna Repair / Jana Krietsch, Michele Rouleau, Michel Lebel -- Cellular Protection Against The Antitumor Drug Bleomycin / Dindial Ramotar Ph.d., Mustapha Aouida Ph.d. -- Atr As A Therapeutic Target / Fiona K. Middleton, Nicola J. Curtin -- Telomeres, Telomerase, And Dna Damage Response In Cancer Therapy / Raina A. Tamakawa, Helen B. Fleisig -- Rad51 Is A Key Protein Of Dna Repair And Homologous Recombination In Humans / Alexander V. Mazin Ph.d., Olga M. Mazina. Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-jamali, Editors. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Front Matter....Pages i-viii Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs....Pages 1-23 DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy?....Pages 25-44 Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses....Pages 45-74 The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy....Pages 75-128 Important Roles of ERCC1 in DNA Repair and Targeted Therapy....Pages 129-142 The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy....Pages 143-155 DNA-PK in CLL Chemotherapy....Pages 157-166 Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair....Pages 167-186 Cellular Protection Against the Antitumor Drug Bleomycin....Pages 187-209 ATR as a Therapeutic Target....Pages 211-228 Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy....Pages 229-279 RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans....Pages 281-302 Back Matter....Pages 303-312 This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin.℗ The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1.℗ Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling ℗ is examined