Advances in Chronic Lymphocytic Leukemia (Advances in Experimental Medicine and Biology Book 792)

"Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia."--Page 4 de la couverture Front Matter....Pages i-xi B Cell Receptor and Antigens in CLL....Pages 1-24 The CLL Cell Microenvironment....Pages 25-45 Acquired Genomic Copy Number Aberrations in CLL....Pages 47-86 Recurrent Gene Mutations in CLL....Pages 87-107 TP53 Aberrations in Chronic Lymphocytic Leukemia....Pages 109-131 Gene Expression and Epigenetic Deregulation....Pages 133-150 Apoptosis Deregulation in CLL....Pages 151-171 Richter Syndrome....Pages 173-191 Molecular Biomarkers in Chronic Lymphocytic Leukemia....Pages 193-214 Critical Signal Transduction Pathways in CLL....Pages 215-239 Immunotherapies in CLL....Pages 241-257 Towards Targeted Therapy of Chronic Lymphocytic Leukemia....Pages 259-291 Inherited Susceptibility to CLL....Pages 293-308 miR Deregulation in CLL....Pages 309-325 Back Matter....Pages 327-334