Advances in Cancer Research, Volume 80 (Advances in Cancer Research)

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented on a variety of topics including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more. Key Features* Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific Antagonists* Tumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial Phenotype* Comparative Analysis of the Transforming Mechanisms of EBV, KSHV, and HVS* Genetic Predisposition and Somatic Diversification in Tumor Development and Progression* Primary Effusion Lymphoma - A Liquid Phase Lymphoma of Fluid-Filled Body Cavities* The Dimensions of Antigen Recognition and the Levels of Immunological Specificity* Topoisomerase I-Mediated DNA Damage Content: Contributors Page ix Involvement of platelet-derived growth factor in disease: development of specific antagonists Review Article Pages 1-38 Arne Östman, Carl-Henrik Heldin Tumor suppression activity of adenovirus e1a protein: Anoikis and the epithelial phenotype Review Article Pages 39-49 Steven M. Frisch Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and herpesvirus saimiri Review Article Pages 51-82 Blossom Damania, Jae U. Jung Genetic predisposition and somatic diversification in tumor development and progression Review Article Pages 83-114 Darryl Shibata, Lauri A. Aaltonen Primary effusion lymphoma: A liquid phase lymphoma of fluid-filled body cavities Review Article Pages 115-146 Gianluca Gaidano, Antonino Carbone Dimensions of antigen recognition and levels of immunological specificity Review Article Pages 147-187 Neil S. Greenspan Topoisomerase I-mediated DNA damage Review Article Pages 189-216 Philippe Pourquier, Yves Pommier Index Pages 217-223 Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented on a variety of topics including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.

Key Features
* Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific Antagonists
* Tumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial Phenotype
* Comparative Analysis of the Transforming Mechanisms of EBV, KSHV, and HVS
* Genetic Predisposition and Somatic Diversification in Tumor Development and Progression
* Primary Effusion Lymphoma - A Liquid Phase Lymphoma of Fluid-Filled Body Cavities
* The Dimensions of Antigen Recognition and the Levels of Immunological Specificity
* Topoisomerase I-Mediated DNA Damage Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, as well as the appearance of the cancer cells. PDGF family members are dimeric molecules with a conserved sequence of about 100 amino acid residues containing a characteristic motif of 8 cysteine residues.