Advances in Cancer Research, Volume 75 (Advances in Cancer Research)

Volume 75 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Graves and Petersen begin the volume with a review of ets proteins and their role in biological specificity. Chapter 2 by Boshoff and Weiss discusses Kaposi's sarcoma and its associated herpesviruses. Chapter 3 by Taipale and colleagues discusses the ways in which the effects of TGF-B can be targeted through its deposition to the extracellular matrix in a latent form. Petersen and colleagues present their research on breast cancer from the phenotypic differentiation standpoint in Chapter 4. The clinical, pathological, and genetic characteristics of hereditary renal carcinoma are reviewed by Zbar and Lerman in Chapter 5. In Chapter 6, Ellem and co-workers discuss the numerous ways in which metastatic cells escape immune killing. Chapter 7 by Kramer et al . Concludes the volume with a discussion on the role of apoptosis via CD95 in liver, colon, and hematopoetic cells. Content: Edited by Page iii Copyright page Page iv Contributors Pages ix-x Specificity within the ets Family of Transcription Factors Original Research Article Pages 1-57 Barbara J. Graves, Jeannine M. Petersen Kaposi's Sarcoma-Associated Herpesvirus Original Research Article Pages 57-87 C. Boshoff, R.A. Weiss Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion Original Research Article Pages 87-134 Jussi Taipale, Juha Saharinen, Jorma Keski-Oja Differentiation and Cancer in the Mammary Gland: Shedding Light on an Old Dichotomy Original Research Article Pages 135-162 Ole W. Petersen, Lone Rønnov-Jessen, Valerie M. Weaver, Mina J. Bissell Inherited Carcinomas of the Kidney Original Research Article Pages 163-203 Berton Zbar, Michael Lerman The Labyrinthine Ways of Cancer Immunotherapy–T Cell, Tumor Cell Encounter: “How Do I Lose Thee? Let Me Count the Ways” Original Research Article Pages 203-249 K.A.O. Ellem, C.W. Schmidt, C.-L. Li, I. Misko, A. Kelso, G. Sing, G. Macdonald, M.G.E. O'Rourke CD95(APO-1/Fas)-Mediated Apoptosis in Normal and Malignant Liver, Colon, and Hematopoietic Cells Original Research Article Pages 251-273 Peter H. Krammer, Peter R. Galle, Peter Möller, Klaus-Michael Debatin Index Pages 275-282 The ets genes encode regulatory transcription factors that share a highly conserved, 85-residue DNA-binding domain, termed the ETS domain. This volume presents critical overviews on select aspects of both cancer research and the basic underlying sciences.