Advances in Cancer Research, Volume 70 (Advances in Cancer Research)

Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series. The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma. Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2 syndromes and the phenotypes associated with ret mutations. Content: Edited by Page iii Copyright page Page iv Contributors Page ix Fundamentals of Cancer Cell Biology Original Research Article Pages 1-19 Michael Stoker The Step-by-Step Development of Epithelial Cancer: From Phenotype to Genotype Original Research Article Pages 21-48 Emmanuel Farber Genetics of the Nevoid Basal Cell Carcinoma Syndrome Original Research Article Pages 49-61 Abirami Chidambaram, Michael Dean Transforming Growth Factor-β System and Its Regulation by Members of the Steroid-Thyroid Hormone Superfamily Original Research Article Pages 63-94 Katri Koli, Jorma Keski-Oja c -M yc in the Controlm of Cell Proliferation and Embryonic Development Original Research Article Pages 95-144 Jean-Marc Lemaitre, Robin S. Buckle, Marcel Méchali Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy Original Research Article Pages 145-177 Steven A. Rosenberg, Yutaka Kawakami, Paul F. Robbins, Rong-fu Wang The Men II Syndromes and the Role of the ret Proto-oncogene Original Research Article Pages 179-222 Bruce A.J. Ponder, Darrin Smith Index Pages 223-229 Presents a review of some of the early advances made by cancer cell biology researchers. This book describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. It illustrates the tumors and associated malformations of nevoid basal cell carcinoma. Cell biology can be described as the study of individual cells, in contrast to tissues, individual molecules, and individual genes.