Advancements of Mass Spectrometry in Biomedical Research (Advances in Experimental Medicine and Biology, 1140)

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field. Front Matter ....Pages i-xxi Mass Spectrometry for Proteomics-Based Investigation (Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha et al.)....Pages 1-26 MALDI Profiling and Applications in Medicine (Ed Dudley)....Pages 27-43 Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry (Yue Ju)....Pages 45-54 Proteome Imaging: From Classic to Modern Mass Spectrometry-Based Molecular Histology (Anca-Narcisa Neagu)....Pages 55-98 Mass Spectrometry-Based Tissue Imaging of Small Molecules (Carly N. Ferguson, Joseph W. M. Fowler, Jonathan F. Waxer, Richard A. Gatti, Joseph A. Loo)....Pages 99-109 Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase (Emily R. Sekera, Troy D. Wood)....Pages 111-119 Proteomics and Non-proteomics Approaches to Study Stable and Transient Protein-Protein Interactions (Armand G. Ngounou Wetie, Izabela Sokolowska, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha, Alisa G. Woods et al.)....Pages 121-142 Contribution of Mass Spectrometry-Based Proteomics to Discoveries in Developmental Biology (Yutaka Hashimoto, Todd M. Greco, Ileana M. Cristea)....Pages 143-154 Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry (Cristian V. A. Munteanu, Gabriela N. Chiriţoiu, Andrei-Jose Petrescu, Ștefana M. Petrescu)....Pages 155-167 The Methods Employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein–Protein Interactions (PPIs) (Rama R. Yakubu, Edward Nieves, Louis M. Weiss)....Pages 169-198 Identification of Posttranslational Modifications (PTMs) of Proteins by Mass Spectrometry (Roshanak Aslebagh, Kelly L. Wormwood, Devika Channaveerappa, Armand G. Ngounou Wetie, Alisa G. Woods, Costel C. Darie)....Pages 199-224 Sequence Variant and Posttranslational Modification Analysis During Cell Line Selection via High-Throughput Peptide Mapping (Chong-Feng Xu, Yan Wang, Pete Bryngelson, Zoran Sosic, Li Zang)....Pages 225-236 Selective Derivatization of Hexahistidine-Tagged Recombinant Proteins (Vasantha Krishna Kadambar, Artem Melman)....Pages 237-250 Investigation of Antibody-Drug Conjugates by Mass Spectrometry (Madhuri Jayathirtha, Costel C. Darie)....Pages 251-263 Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides (Marius Mihăşan, Kelly L. Wormwood, Izabela Sokolowska, Urmi Roy, Alisa G. Woods, Costel C. Darie)....Pages 265-287 Strategies for Membrane Protein Analysis by Mass Spectrometry (Rafael C. Prados-Rosales, Guillermo Aragoneses-Cazorla, Hector Estevez, Estefania Garcia-Calvo, Andres Machuca, Jose L. Luque-Garcia)....Pages 289-298 The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses (Kelly L. Wormwood, Liulin Deng, Ahmed M. Hamid, Daniel DeBord, Laura Maxon)....Pages 299-316 Application of Ion Mobility Mass Spectrometry in Lipidomics (Fereshteh Zandkarimi, Lewis M. Brown)....Pages 317-326 Mass Spectrometry in Advancement of Redox Precision Medicine (Xiaofei Chen, Jingyun Lee, Hanzhi Wu, Allen W. Tsang, Cristina M. Furdui)....Pages 327-358 Applications for Mass Spectrometry in the Study of Ion Channel Structure and Function (Damien S. K. Samways)....Pages 359-375 Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance (Laura Ion, Brînduşa Alina Petre)....Pages 377-388 Developing Well-Annotated Species-Specific Protein Databases Using Comparative Proteogenomics (Emmalyn J. Dupree, Bernard S. Crimmins, Thomas M. Holsen, Costel C. Darie)....Pages 389-400 Stoichiometry of Heavy Metal Binding to Peptides Involved in Alzheimer’s Disease: Mass Spectrometric Evidence (Monica Jureschi, Ancuta Veronica Lupaescu, Laura Ion, Brînduşa Alina Petre, Gabi Drochioiu)....Pages 401-415 Role of Mass Spectrometry in Investigating a Novel Protein: The Example of Tumor Differentiation Factor (TDF) (Izabela Sokolowska, Armand G. Ngounou Wetie, Alisa G. Woods, Madhuri Jayathirtha, Costel C. Darie)....Pages 417-433 Mass Spectrometry-Based Biomarkers in Drug Development (Michelle R. Robinson, Ronald A. Miller, Daniel S. Spellman)....Pages 435-449 Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery (Roshanak Aslebagh, Devika Channaveerappa, Brian T. Pentecost, Kathleen F. Arcaro, Costel C. Darie)....Pages 451-467 Proteomic Approaches to Dissect Neuronal Signalling Pathways (Heather L. Bowling, Shruti Nayak, Katrin Deinhardt)....Pages 469-475 Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders (Kelly L. Wormwood, Armand G. Ngounou Wetie, Jeanne P. Ryan, Costel C. Darie, Alisa G. Woods)....Pages 477-499 Simplifying the Proteome: Analytical Strategies for Improving Peak Capacity (Lee A. Gethings, Joanne B. Connolly)....Pages 501-513 Exploration of Nicotine Metabolism in Paenarthrobacter nicotinovorans pAO1 by Microbial Proteomics (Marius Mihăşan, Cornelia Babii, Roshanak Aslebagh, Devika Channaveerappa, Emmalyn J. Dupree, Costel C. Darie)....Pages 515-529 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics (Esthelle Hoedt, Guoan Zhang, Thomas A. Neubert)....Pages 531-539 Mass Spectrometry Based Comparative Proteomics Using One Dimensional and Two Dimensional SDS-PAGE of Rat Atria Induced with Obstructive Sleep Apnea (Devika Channaveerappa, Brian K. Panama, Costel C. Darie)....Pages 541-561 2D SDS PAGE in Combination with Western Blotting and Mass Spectrometry Is a Robust Method for Protein Analysis with Many Applications (Nancy Kendrick, Costel C. Darie, Matt Hoelter, Ginny Powers, Jon Johansen)....Pages 563-574 Pulse SILAC Approaches to the Measurement of Cellular Dynamics (Justin Snider, Daifeng Wang, Daniel F. Bogenhagen, John D. Haley)....Pages 575-583 Protein Biomarkers in Major Depressive Disorder: An Update (Alisa G. Woods, Kelly L. Wormwood, Dan V. Iosifescu, James Murrough, Costel C. Darie)....Pages 585-600 A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy (Emmalyn J. Dupree, Aurora Goodwin, Costel C. Darie, Ali Boolani)....Pages 601-611 Metabolomics and Biomarker Discovery (Kathryn Sinclair, Ed Dudley)....Pages 613-633 Analytical Methods for Mass Spectrometry-Based Metabolomics Studies (Siyu Wang, Ian A. Blair, Clementina Mesaros)....Pages 635-647 Trends in Analysis of Cortisol and Its Derivatives (Ali Boolani, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha, Roshanak Aslebagh, Stephanie Grobe et al.)....Pages 649-664 Detection of Biomedically Relevant Stilbenes from Wines by Mass Spectrometry (Veronica Andrei, Dana Copolovici, Florentina-Daniela Munteanu, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie et al.)....Pages 665-684 Mass Spectrometry as a Complementary Approach for Noncovalently Bound Complexes Based on Cyclodextrins (Mihaela Silion, Adrian Fifere, Ana Lacramioara Lungoci, Narcisa Laura Marangoci, Sorin Alexandru Ibanescu, Radu Zonda et al.)....Pages 685-701 Trends in Glycolipid Biomarker Discovery in Neurodegenerative Disorders by Mass Spectrometry (Liana Dehelean, Mirela Sarbu, Alina Petrut, Alina D. Zamfir)....Pages 703-729 Non-targeted Screening in Environmental Monitoring Programs (Bernard S. Crimmins, Thomas M. Holsen)....Pages 731-741 Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and Its Future Use for the Molecular Epidemiology of Cancer (Bernhard H. Monien)....Pages 743-751 Bottlenecks in Proteomics: An Update (Devika Channaveerappa, Armand G. Ngounou Wetie, Costel C. Darie)....Pages 753-769 Recent Applications of Mass Spectrometry at Clarkson University (Madhuri Jayathirtha, Danielle Whitham, Sydney Stradtman, Costel C. Darie)....Pages 771-785 Correction to: 2D SDS PAGE in Combination with Western Blotting and Mass Spectrometry Is a Robust Method for Protein Analysis with Many Applications (Nancy Kendrick, Costel C. Darie, Matt Hoelter, Ginny Powers, Jon Johansen)....Pages C1-C1 Back Matter ....Pages 787-813