Advanced Organic Chemistry, Fourth Edition - Part B: Reaction and Synthesis (Advanced Organic Chemistry / Advanced Organic Chemistry)

Since its original appearance in 1977, Advanced Organic Chemistry has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds. The Fourth Edition provides updated material but continues the essential elements of the previous edition. The material in Part A is organized on the basis of fundamental structural topics such as structure, stereochemistry, conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions. The material in Part B is organized on the basis of reaction type with emphasis on reactions of importance in laboratory synthesis. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The Fourth Edition updates certain topics that have advanced rapidly in the decade since the Third Edition was published, including computational chemistry, structural manifestations of aromaticity, enantioselective reactions and lanthanide catalysis. The two parts stand alone, although there is considerable cross-referencing. Part A emphasizes quantitative and qualitative description of structural effects on reactivity and mechanism. Part B emphasizes the most general and useful synthetic reactions. The focus is on the core of organic chemistry, but the information provided forms the foundation for future study and research in medicinal and pharmaceutical chemistry, biological chemistry and physical properties of organic compounds.

The control of reactivity to achieve specific syntheses is one of the overarching goals of organic chemistry. In the decade since the publication of the third edition, major advances have been made in the development of efficient new methods, particularly catalytic processes, and in means for control of reaction stereochemistry.
This volume assumes a level of familiarity with structural and mechanistic concepts comparable to that in the companion volume, Part A, Structures and Mechanisms. Together, the two volumes are intended to provide the advanced undergraduate or beginning graduate student in chemistry with a sufficient foundation to comprehend and use the research literature in organic chemistry.

The New Revised 5th Edition will be available shortly. For details, click on the link in the right-hand column.

Part A of a new edition of a two-volume text on organic chemistry that aims to solidify and extend the student's understanding of basic concepts and to illustrate how structural changes influence mechanism and reactivity. In this volume, Francis A. Carey and Richard J. Sundberg (U. of Virginia) update the fundamental topics of structure and mechanism. Topics include molecular structure (chemical bonding, stereochemistry, and conformation); methods for characterization of reaction mechanisms; aromaticity; fundamental reaction types (nucleophilic substitution, addition and elimination, carbanions, carbonyl chemistry, aromatic substitution, pericyclic and free radical reactions, and photochemistry). Annotation copyrighted by Book News, Inc., Portland, OR "The material in this book is organized on the basis of fundamental structural topics such as structure, stereochemistry conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions." Concentrating on the most important reactions used for organic synthesis, this upper-level textbook presents the material by reaction type. The final chapter discusses the planning and execution of multi-step synthesis. Carbon-carbon bond formation is the basis for the construction of the molecular framework of organic molecules by synthesis.