Adult Stem Cells (Stem Cell Biology and Regenerative Medicine)

__Adult Stem Cells__, second edition, takes a critical look at issues concerning the developmental or differentiation potential for a variety of tissue types and for specific adult stem cell types. Since the first edition appeared a decade ago, our understanding of adult stem cells, and more specifically tissue-specific adult stem cells, has advanced tremendously. And an increased interest in regenerative medicine and potential stem cell applications has driven a quest for better understanding of stem cell biology. In turn, this has spawned much activity on generation and utilization of more and better reagents to identify and isolate stem cells and stem cell-like subpopulations, and on assays elucidating their developmental or differentiation potential and functional integration with host tissues and organs. In this fully updated new edition, chapters cover topics ranging from signaling pathways maintaining stemness in hematopoietic cells to regeneration after injury and endocrine mechanisms underlying the stem cell theory of aging. Other chapters cover stem cells by organ or system including pituitary, cardiac, epithelial, teeth, lung, ovary, prostate, liver, and many more. Importantly, the authors of the chapters have not only summarized their successes, but have also summarized some of the difficulties that each particular field is still facing with respect to maximizing the utility of stem cells in clinical settings. Collectively, they impart both the excitement and challenges facing stem cell utilization for repair and regeneration making this book essential reading for those involved in stem cell research as well as those involved in clinical assays. Front Matter....Pages i-xiii Signaling Pathways Maintaining Stemness in Adult Hematopoietic Stem Cells....Pages 1-13 The Adult Stem Cell Niche....Pages 15-30 Adult Stem Cells: Adult Skeletal Muscle Stem Cells....Pages 31-45 Adult Cardiac Stem Cells: Identity, Location and Potential....Pages 47-90 Adult Pituitary Stem Cells....Pages 91-109 Toward Translating Molecular Ear Development to Generate Hair Cells from Stem Cells....Pages 111-161 Adult Human Corneal Epithelial Stem Cells....Pages 163-197 Adult Stem Cells in Teeth....Pages 199-216 Adult Mammary Stem Cells: Identity, Location, and Functional Assays....Pages 217-237 Adult Ovary Stem Cells....Pages 239-264 Adult Prostate Stem Cells....Pages 265-286 Adult Lung Stem Cells....Pages 287-318 Adult Liver Stem Cells....Pages 319-338 Lineage-Committed Pancreatic Progenitors and Stem Cells....Pages 339-357 Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications....Pages 359-373 Regeneration After Injury: Activation of Stem Cell Stress Response Pathways to Rapidly Repair Tissues....Pages 375-387 Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging....Pages 389-417 Back Matter....Pages 419-429