Adipose Tissue in Health and Disease [ISBN : 9783527318575] [Copyright Year : 2010] [Hardcover]

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.Content: Chapter 1 Transcriptional Control of Adipogenesis and Fat Cell Gene Expression (pages 1–20): Ursula A. White and Jacqueline M. Stephens Chapter 2 Cellular and Molecular Basis of Functional Differences among Fat Depots (pages 21–47): Thomas Thomou, Tamara Tchkonia and James L. Kirkland Chapter 3 Plasticity of the Adipose Organ (pages 49–67): Saverio Cinti Chapter 4 Biology of Adipose Tissue Stem Cells (pages 69–80): Jeffrey M. Gimble, Bruce A. Bunnell and Farshid Guilak Chapter 5 Molecular Mechanisms of Adipocyte Lipolysis (pages 81–96): James G. Granneman and Hsiao?Ping H. Moore Chapter 6 New Developments in the Lipolytic Processing of Triglyceride?Rich Lipoproteins (pages 97–108): Andre Bensadoun, Anne P. Beigneux, Loren G. Fong and Stephen G. Young Chapter 7 Intracellular Fatty Acid Transport, Activation, and Trafficking (pages 109–127): Doug Mashek Chapter 8 Aquaporins and Adipose Tissue: Lesson from Discovery to Physiopathology and to the Clinic of Aquaporin Adipose (AQP7) (pages 129–147): Ken Kishida Chapter 9 Signaling Pathways Controlling Lipolysis and Lipid Mobilization in Humans (pages 149–179): Max Lafontan Chapter 10 Leptin Secretion and Action (pages 181–199): Robert V. Considine Chapter 11 Adiponectin (pages 201–230): Jonathan P. Whitehead and Ayanthi A. Richards Chapter 12 Preadipocyte Factor?1 and Adipose Tissue?Specific Secretory Factor/Resistin – Two Secreted Factors from Adipose Tissue: Role in Adipogenesis and Insulin Resistance (pages 231–243): Hei Sook Sul, Yuhui Wang and Carolyn Hudak Chapter 13 Adipose Tissue and Blood Pressure Regulation (pages 245–263): Lisa A. Cassis and Sara B. Police Chapter 14 Adipokines, Inflammation, and Obesity (pages 265–281): Karine Clement Chapter 15 Depot?Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk (pages 283–306): Mi?Jeong Lee and Susan K. Fried Chapter 16 Viral Induction of Obesity and Adipogenesis (pages 307–332): Magdalena Pasarica, Rohan N. Dhurandhar, Nazar Mashtalir and Nikhil V. Dhurandhar Chapter 17 Adipose Tissue Cachexia (pages 333–345): Michael John Tisdale Chapter 18 Obesity and Diabetes: Lipotoxicity (pages 347–368): Christopher J. Lelliott, Matej Oresic and Antonio J. Vidal?Puig Chapter 19 Obesity and Cancer (pages 369–384): Andrew G. Renehan Chapter 20 Overview of Acquired and Genetic Lipodystrophies (pages 385–402): Tisha Joy and Robert A. Hegele Chapter 21 Mouse Models of Lipodystrophy (pages 403–422): Jimmy Donkor and Karen Reue Chapter 22 Caloric Restriction, Longevity, and Adiposity (pages 423–439): Leanne M. Redman and Eric Ravussin Chapter 23 Peroxisome Proliferator?Activated Receptor??: A Key Regulator of Adipose Tissue Formation, Remodeling, and Metabolism (pages 441–458): Olga Astapova and Todd Leff Chapter 24 Early?Life Programming of Adipogenesis and Adiposity (pages 459–472): Roselle L. Cripps and Susan E. Ozanne Chapter 25 Evolutionary Aspects of Obesity and Adipose Tissue Function (pages 473–490): Jonathan C. K. Wells Front Matter Adipose Tissue Development and Morphology Transcriptional Control of Adipogenesis and Fat Cell Gene Expression / Ursula A. White, Jacqueline M. Stephens Cellular and Molecular Basis of Functional Differences among Fat Depots / Thomas Thomou, Tamara Tchkonia, James L. Kirkland Plasticity of the Adipose Organ / Saverio Cinti Biology of Adipose Tissue Stem Cells / Jeffrey M. Gimble, Bruce A. Bunnell, Farshid Guilak Metabolic Functions of Adipose Tissue. Molecular Mechanisms of Adipocyte Lipolysis / James G. Granneman, Hsiao-Ping H. Moore New Developments in the Lipolytic Processing of Triglyceride-Rich Lipoproteins / André Bensadoun, Anne P. Beigneux, Loren G. Fong, Stephen G. Young Intracellular Fatty Acid Transport, Activation, and Trafficking / Doug Mashek Aquaporins and Adipose Tissue: Lesson from Discovery to Physiopathology and to the Clinic of Aquaporin Adipose (AQP7) / Ken Kishida ^ Signaling Pathways Controlling Lipolysis and Lipid Mobilization in Humans / Max Lafontan Endocrine Functions of Adipose Tissue Leptin Secretion and Action / Robert V. Considine Adiponectin / Jonathan P. Whitehead, Ayanthi A. Richards Preadipocyte Factor-1 and Adipose Tissue-Specific Secretory Factor/Resistin-Two Secreted Factors from Adipose Tissue: Role in Adipogenesis and Insulin Resistance / Hei Sook Sul, Yuhui Wang, Carolyn Hudak Adipose Tissue and Blood Pressure Regulation / Lisa A. Cassis, Sara B. Police Adipokines, Inflammation, and Obesity / Karine Cľment Adipose Tissue and Disease. Depot-Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk / Mi-Jeong Lee, Susan K. Fried Viral Induction of Obesity and Adipogenesis / Magdalena Pasarica, Rohan N. Dhurandhar, Nazar Mashtalir, Nikhil V. Dhurandhar Adipose Tissue Cachexia / Michael John Tisdale ^ ^^ Obesity and Diabetes: Lipotoxicity / Christopher J. Lelliott, Matej Orešič, Antonio J Vidal-Puig Obesity and Cancer / Andrew G Renehan Overview of Acquired and Genetic Lipodystrophies / Tisha Joy, Robert A Hegele Mouse Models of Lipodystrophy / Jimmy Donkor, Karen Reue Caloric Restriction, Longevity, and Adiposity / Leanne M. Redman, Eric Ravussin Peroxisome Proliferator-Activated Receptor-?: A Key Regulator of Adipose Tissue Formation, Remodeling, and Metabolism / Olga Astapova, Todd Leff Early-Life Programming of Adipogenesis and Adiposity / Roselle L. Cripps, Susan E. Ozanne Evolutionary Aspects of Obesity and Adipose Tissue Function / Jonathan C.K. Wells Index. ^^ Transcriptional control of adipogenesis and fat cell gene expression / Ursula A. White and Jacqueline M. Stephens Cellular and molecular basis of functional differences among fat depots / Thomas Thomou, Tamara Tchkonia, and James L. Kirkland Plasticity of the adipose organ / Saverio Cinti Biology of adipose tissue stem cells / Jeffrey M. Gimble, Bruce A. Bunnell, and Farshid Guilak Molecular mechanisms of adipocyte lipolysis / James G. Granneman and Hsiao-Ping H. Moore New developments in the lipolytic processing of triglyceride-rich lipoproteins / Andre Bensadoun ... [et al.] Intracellular fatty acid transport, activation, and trafficking / Doug Mashek Aquaporins and adipose tissue: lesson from discovery to physiopathology and to the clinic of aquaporin adipose (AQP7) / Ken Kishida Signaling pathways controlling lipolysis and lipid mobilization in humans / Max Lafontan Leptin secretion and action / Robert V. Considine Adiponectin / Jonathan P. Whitehead and Ayanthi A. Richards Preadipocyte factor-1 and adipose tissue-specific secretory factor/resistin two secreted factors from adipose tissue: role in adipogenesis and insulin resistance / Hei Sook Sul, Yuhui Wang, and Carolyn Hudak Adipose tissue and blood pressure regulation / Lisa A. Cassis and Sara B. Police Adipokines, inflammation, and obesity / Karine Clement Depot-specific biology of adipose tissues: links to fat distribution and metabolic risk / Me-Jeong Lee and Susan K. Fried Viral induction of obesity and adipogenesis / Magdalena Pasarica ... [et al.] Adipose tissue cachexia / Michael John Tisdale Obesity and diabetes: lipotoxicity / Christopher J. Lelliot, Matej Oresic, and Antonio J. Vidal-Puig Obesity and cancer / Andrew G. Renehan Overview of acquired and genetic lipodystrophies / Tisha Joy and Robert A. Hegele Mouse models of lipodystrophy / Jimmy Donkor and Karen Reue The study of adipose tissue is directly related to our understanding of obesity and clinically important diseases in developed countries, in particular diabetes and cardiovascular disease. This unique handbook presents a comprehensive overview of adipose tissue in health and disease, covering all different aspects of the topic. It is an essential resource on a topic vital for fighting the worldwide obesity epidemic. It discusses recent discoveries. It covers a wide range of different diseases. It describes conditions or pathological processes associated with diseases. It addresses an extensive interdisciplinary target group. It meets the major interest and investment in the topic from the pharmaceutical industry. The book describes in detail the adipose tissue development and morphology before moving on to metabolic functions of adipose tissue. The volume then focuses on the endocrine functions, the relationship between adipose tissue and disease, and closes with the comparative and evolutionary aspects of adipose tissue