Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease (Handbook of Experimental Pharmacology 234)

"Latest research on adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how adhesion GPCRs signal and how these receptors shape organ structure and function"--Publisher's description Front Matter....Pages i-xiv Introduction: History of the Adhesion GPCR Field....Pages 1-11 Front Matter....Pages 13-13 Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs....Pages 15-41 7TM Domain Structure of Adhesion GPCRs....Pages 43-66 Understanding the Structural Basis of Adhesion GPCR Functions....Pages 67-82 Control of Adhesion GPCR Function Through Proteolytic Processing....Pages 83-109 Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs....Pages 111-125 Versatile Signaling Activity of Adhesion GPCRs....Pages 127-146 Adhesion GPCR-Related Protein Networks....Pages 147-178 The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans....Pages 179-217 Front Matter....Pages 219-219 Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors....Pages 221-247 Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration....Pages 249-274 Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination....Pages 275-298 Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs....Pages 299-308 Adhesion GPCR Function in Pulmonary Development and Disease....Pages 309-327 Adhesion GPCRs as Modulators of Immune Cell Function....Pages 329-350 Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs....Pages 351-368 Adhesion GPCRs in Tumorigenesis....Pages 369-396 Back Matter....Pages 397-403