Adenosine Receptors in Health and Disease (Handbook of Experimental Pharmacology (193))

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs. Front Matter....Pages i-xiii Introduction to Adenosine Receptors as Therapeutic Targets....Pages 1-24 A 1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers....Pages 25-58 Recent Developments in Adenosine A 2A Receptor Ligands....Pages 59-98 Recent Developments in A 2B Adenosine Receptor Ligands....Pages 99-122 Medicinal Chemistry of the A 3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering....Pages 123-159 Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology....Pages 161-188 Adenosine Receptors and Reperfusion Injury of the Heart....Pages 189-214 Adenosine Receptors and Inflammation....Pages 215-269 A 1 Adenosine Receptor: Role in Diabetes and Obesity....Pages 271-295 A 3 Adenosine Receptor: Pharmacology and Role in Disease....Pages 297-327 Adenosine Receptors and Asthma....Pages 329-362 Adenosine Receptors, Cystic Fibrosis, and Airway Hydration....Pages 363-381 Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis....Pages 383-397 Adenosine Receptors and Cancer....Pages 399-441 Adenosine Receptors and the Kidney....Pages 443-470 Adenosine Receptors and the Central Nervous System....Pages 471-534 Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration....Pages 535-587 Adenosine A 2A Receptors and Parkinson’s Disease....Pages 589-615 Adenosine Receptor Ligands and PET Imaging of the CNS....Pages 617-642 Back Matter....Pages 643-652 Introduction To Adenosine Receptors As Therapeutic Targets -- A1 Adenosine Receptor Antagonists, Agonists, And Allosteric Enhancers -- Recent Developments In Adenosine A2[a] Receptor Ligands -- Recent Developments In A2[b] Adenosine Receptor Ligands -- Medicinal Chemistry Of The A3 Adenosine Receptor: Agonists, Antagonists, And Receptor Engineering -- Adenosine Receptors And The Heart: Role In Regulation Of Coronary Blood Flow And Cardiac Electrophysiology -- Adenosine Receptors And Reperfusion Injury Of The Heart -- Adenosine Receptors And Inflammation -- A1 Adenosine Receptor: Role In Diabetes And Obesity -- A3 Adenosine Receptor: Pharmacology And Role In Disease -- Adenosine Receptors And Asthma -- Adenosine Receptors, Cystic Fibrosis, And Airway Hydration -- Adenosine Receptors In Wound Healing, Fibrosis And Angiogenesis -- Adenosine Receptors And Cancer -- Adenosine Receptors And The Kidney -- Adenosine Receptors And The Central Nervous System -- Adenosine Receptors And Neurological Disease: Neuroprotection And Neurodegeneration -- Adenosine A2[a] Receptors And Parkinson's Disease -- Adenosine Receptor Ligands And Pet Imaging Of The Cns. Constance N. Wilson, S. Jamal Mustafa, Editors ; Contributors, M.p. Abbracchio ... [et Al.]. Includes Bibliographical References And Index.