Addressing the Threat of Drug-Resistant Tuberculosis : A Realistic Assessment of the Challenge - Workshop Summary

Tuberculosis Is One Of The Leading Causes Of Death In The World Today, With 4,500 People Dying From The Disease Every Day. Many Cases Of Tb Can Be Cured By Available Antibiotics, But Some Tb Is Resistant To Multiple Drugs--a Major And Growing Threat Worldwide. The Institute Of Medicine's Forum On Drug Discovery, Development, And Translation Hosted A Workshop On November 5, 2008, To Address The Mounting Concern Of Drug-resistant Tb. The Session Brought Together A Wide Range Of International Experts To Discuss What Is Known And Not Known About This Growing Threat, And To Explore Possible Solutions.--publisher's Website. Introduction -- The Global Spread Of Multidrug-resistant And Extensively Drug-resistant Tuberculosis -- Mdr Tb Transmission, Hiv Coinfection, And Transmission Control -- Diagnosis -- Infrastructure And Health Care Delivery Systems -- Global Systems For The Purchase And Delivery Of Tb Drugs -- Research On The Global Control Of Tb: Understanding The Role Of Drugs, Vaccines, And Funding -- Strategies For Confronting The Global Mdr And Xdr Tb Crisis -- Appendix A. Agenda -- Appendix B. Participant Biographies -- Appendix C. Partners In Health White Paper: Stemming The Tide Of Multidrug-resistant Tuberculosis : Major Barriers To Addressing The Growing Epidemic. Robert Giffin And Sally Robinson, Rapporteurs ; Institute Of Medicine Of The National Academies. The Institute Of Medicine's (iom's) Forum On Drug Discovery, Development, And Translation Held A Workshop In Washington, Dc, On November 5, 2008--p. 2. Includes Bibliographical References. Also Issued Online. FrontMatter......Page 2 Reviewers......Page 10 Contents......Page 12 Tables, Figures, and Boxes......Page 14 Acronyms......Page 16 Summary......Page 18 1 Introduction......Page 32 2 The Global Spread of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis......Page 36 3 MDR TB Transmission, HIV Coinfection, and Transmission Control......Page 52 4 Diagnosis......Page 68 5 Infrastructure and Health Care Delivery Systems......Page 76 6 Global Systems for the Purchase and Delivery of TB Drugs......Page 84 7 Research on the Global Control of TB: Understanding the Role of Drugs, Vaccines, and Funding......Page 98 8 Strategies for Confronting the Global MDR and XDR TB Crisis......Page 114 References......Page 126 Appendix A: Agenda......Page 130 Appendix B: Participant Biographies......Page 134 Appendix C: Partners In Health White Paper—Stemming the Tide of Multidrug-Resistant Tuberculosis: Major Barriers to Addressing the Growing Epidemic......Page 156