Adalat in the Asian Pacific region : 3rd Asian Pacific adalat symposium : Papers

These are the proceedings of the third Asian Pacific Adalat Symposium. The first was held in Tokyo in 1982 and the second in Sydney in 1985. We were honoured that the late Dr. Sukaman and his colleagues were able to host this third symposium in Jakarta. This meeting was designed to contribute to and to promote international collaboration in cardiovascular research, and to help promote further knowledge and understanding about the treatment of vascular disease in the Asian Pacific area. Nifedipine was originally investigated in the mid-1960s by Prof. Fleckenstein. His first results showed this drug was a powerful calcium antagonist which altered excitation contraction. At this time, there was a rapid development of knowledge about the pathophysiology of ischaemic heart disease, and thus the important pharmacological work on calcium antagonists such as nifedipine paralleled and complimented the newer understanding of coronary physiology in man. In a short time most therapy was designed to reduce myocardial oxygen consumption and demand. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Study on the Clinical Effectiveness of Adalat L Tablet for Angina Pectoris: A Double-blind Study with Adalat as a Reference Drug....Pages 3-11 Nifedipine-Induced Reperfusion in Stable Angina and Postinfarction Cases....Pages 12-25 Newest Information on Unstable Angina Pectoris....Pages 26-33 Effect of Nifedipine on Relaxation and Early Left Ventricular Filling During Postpacing Ischemic Period....Pages 34-44 Front Matter....Pages 45-45 Effect of Nifedipine on Atherosclerosis in Cholesterol-Fed Rabbits and Watanabe Heritable Hyperlipidemic Rabbits....Pages 47-59 Natural History of Coronary Artery Disease: The Effects of Ca 2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis....Pages 60-73 Effect of Nifedipine on DNA Synthesis and Cytosolic Free Calcium Concentration Stimulated by Growth Factors: A Study Using Cultured Rat Aortic Smooth-Muscle Cells....Pages 74-81 Front Matter....Pages 83-83 Studies on the Mechanism of the Antihypertensive Effect of Long-Term Administered Nifedipine in Patients with Benign Essential Hypertension....Pages 85-96 Nifedipine Retard as Monotherapy for Essential Hypertension: A Randomized Controlled Cross-over Study....Pages 97-102 Long-Term Treatment of Hypertensive Patients with Nifedipine Tablet....Pages 103-108 Hemodynamic and Neurohumoral Effects of Nifedipine Slow-Release Tablet in the Treatment of Hypertension....Pages 109-118 Front Matter....Pages 119-119 Effect of Nifedipine on Serum Lipoprotein Metabolism in Patients with Essential Hypertension....Pages 121-126 Effects of Nifedipine on Cardiovascular System, with Special Reference to Coronary Circulation....Pages 127-132 Back Matter....Pages 133-138 This book deals with the symposium held in Jakarta on calcium antagonist therapy which was sponsored by Bayer AG on the calcium antagonist drug Nifedipine. This drug is used extensively in the Asian Pacific area for the treatment of hypertension, a common disease in this region, and also for ischaemic heart disease. It details both basic pharmacology and research studies in the Asian Pacific region in the field of hypertension and ischaemic heart disease and as such is of considerable interest to cardiologists in the region