Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)

Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy. This Volume Is Meant To Summarize Some Of The Most Recent Progress Made In Elucidating The Pathogenesis Of Acute Promyelocytic Leukemia (apl) And In The Treatment Of This Form Of Leukemia. It Is Also Meant To Celebrate One Of The Most Successful Accomplishments In Cancer Research And Contemporary Biomedical Research.--book Jacket. Apl As A Paradigm In Biomedical Research : A Journey Toward The Cure / P.p. Pandolfi -- Mouse Models Of Acute Promyelocytic Leukemia / S.c. Kogan -- The Plzf Gene Of T(11;17)-associated Apl / M.j. Mcconnell And J.d. Licht -- Sumo, The Three Rs And Cancer / J.-s. Seeler [and Others] -- Emerging Role For Micrornas In Acute Promyelocytic Leukemia / C. Nervi [and Others] -- The Theory Of Apl Revisited / P.p. Scaglioni And P.p. Pandolfi -- Treatment Of Acute Promyelocytic Leukemia By Retinoids / P. Fenaux, Z.z. Wang, And L. Degos -- Arsenic Trioxide And Acute Promyelocytic Leukemia : Clinical And Biological / Z. Chen [and Others] -- Front Line Clinical Trials And Minimal Residual Disease Monitoring In Acute Promyelocytic Leukemia / F. Lo-coco And E. Ammatuna -- Histone Deacetylase Inhibitors In Apl And Beyond / K. Petrie, N. Prodomou, And A. Zelent -- Monoclonal Antibody Therapy Of Apl / P.g. Maslak, J.g. Jurcic, And D.a. Scheinberg -- Targeting Apl Fusion Proteins By Peptide Interference / A. Melnick -- The Design Of Selective And Non-selective Combination Therapy For Acute Promyelocytic Leukemia / Y. Jing And S. Waxman. P.p. Pandolfi And P.k. Vogt (eds.). Includes Bibliographical References And Index.