Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management (Current Clinical Urology)

Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy. Front Matter....Pages i-xi The Problem of Cancer Overdiagnosis and Overtreatment....Pages 1-7 Patient Selection for Active Surveillance....Pages 9-21 Predicting High-Risk Disease Using Tissue Biomarkers....Pages 23-34 Predicting High-Risk Disease Using Serum and DNA Biomarkers....Pages 35-54 Triggers for Intervention in Men on Surveillance....Pages 55-65 The Role of MRI in Active Surveillance....Pages 67-80 Active Surveillance: The European Experience....Pages 81-94 Active Surveillance: The Canadian Experience....Pages 95-105 Psychosocial Aspects of AS....Pages 107-119 Statistical Considerations for Patient Selection and Triggers for Intervention in Active Surveillance....Pages 121-129 Interpreting PSA Kinetics Using GLMM Technique....Pages 131-137 The Potential Benefits of Diet and Physical Activity Among Active Surveillance Patients with Low-Burden Prostate Cancer....Pages 139-152 The Role of 5α-Reductase Inhibitors (5-ARIs) in Expectant Management of Low-Risk Prostate Cancer....Pages 153-156 Urologists’ Opinion on Active Surveillance: USA Versus the Netherlands....Pages 157-168 Clinical “Pearls” in Managing Patients on Surveillance....Pages 169-172 Active Surveillance, Focal Therapy, and the Future....Pages 173-178 The Economics of Active Surveillance for Prostate Cancer....Pages 179-185 The Future of Active Surveillance....Pages 187-199 Back Matter....Pages 201-208 This book explores active surveillance in prostate cancer, covering patient selection, risk assessment, `cancer hysteria' in patients, identifying triggers for intervention, use of PSA kinetics and MRI information and the roles of surveillance and focal therapy. Laurence Klotz, Editor. Includes Bibliographical References And Index.