Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences (Nato Science Series C:, 295)

This volume contains the papers presented in the NATO Advanced Research Workshop "Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences" held in Nafplion, Greece on September 25-30, 1988. The objective of NATO ARW is to assess the state of-the-art in a given scientific area and to formulate recommendations for future research in emerging areas of science by promoting international scientific contacts. In the Nafplion meeting this objective was reached by an international group of speakers, senior Greek scientists and graduates involved in relevant research areas. The Workshop was made possible by the generous support of the Scientific Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, Directors of the NATO ARW's and ASI's (Advanced Study Institutes) respectively, for their wholehearted support and advice. The International Union of Biochemistry awarded additional travel grants leading to increased international participation. Furthermore, the Secretariat of Science and Technology, the Ministry of Culture and Sciences and the National Hellenic Research Foundation contributed financially and by supporting personnel. We sincerely thank all these organizations for their support. Our heartful thanks are also extended to the Mayor of the Municipality of Nafplion, Mr. Front Matter....Pages i-xxi “Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences”: A Record of the Meeting....Pages 1-6 Front Matter....Pages 7-7 Insulin Receptor and Insulin Action....Pages 9-17 Signal Transduction by Growth Factor Receptors....Pages 19-25 Cholera Toxin: Transport and Structural Basis of Action....Pages 27-40 Analysis and Transfection of Human Acidic Fibroblast Growth Factor (aFGF) cDNA Clones and Structural Analysis of the Human aFGF Gene reveals Features Shared within a Family of Homologous Proteins....Pages 41-48 Growth Factor Synthesis By a Human Teratocarcinoma Cell Line: Implications for Autocrine Growth in the Human Embryo?....Pages 49-59 Front Matter....Pages 61-61 The Role of Ras P21 Product in Cell Transformation....Pages 63-67 DNA Binding Properties of the Thyroid Hormone Receptor/c-erbA Protein and Its Viral Homologue P75 gag-v-erbA ....Pages 69-75 The Role of FOS in Gene Regulation....Pages 77-91 6-Phosphofructo-2-Kinase Links Glycolysis to Mitogenic Agents and has Sequence Similarity with Proteins Encoded by Oncogenic DNA Viruses....Pages 93-102 Front Matter....Pages 103-103 The Regulation of RNA Polymerase II Activity by Multisite Phosphorylation....Pages 105-117 Transcription Factors of RNA Polymerase III from Mammalian Cells....Pages 119-136 Steroid Response Elements: Composite Structure and Definition of a Minimal Element....Pages 137-150 Gene Regulation by Steroid Hormones....Pages 151-172 Regulation of Liver Gene Expression in Dexamethasone Resistant Hepatoma Cells....Pages 173-193 The Kinetics of Oestrogen-Induced Gene Expression in the Immature Rat Uterus....Pages 195-199 Front Matter....Pages 201-201 Functional Domains of Steroid Hormone Receptors....Pages 203-213 Genetic and Biochemical Analysis of a Steroid Receptor....Pages 215-225 Analysis of Subunit Interactions in Steroid Receptors Using Chemical Cross-Linking....Pages 227-237 Possible Functional Interaction Between Steroid Hormone Receptors and Heat Shock Protein M r 90.000 (hsp 90)....Pages 239-256 Front Matter....Pages 201-201 Mechanism of Action of Estrogens: Phosphorylation of Estradiol Receptor on Tyrosine....Pages 257-267 Glucocorticoid Receptor and Hormonal Extragenomic Effects....Pages 269-286 Front Matter....Pages 287-287 Estrogen Receptors in Mouse Mammary Tumors....Pages 289-294 Structure of Glucocorticoid Receptor in Cancer Tissues....Pages 295-315 Back Matter....Pages 317-320 Proceedings of the NATO Advanced Research Workshop, Nafplion, Greece, September 25-30, 1988