Actin : biophysics, biochemistry and cell biology; [proceedings of an international conference on the Biophysics, Biochemistry, and Cell Biology of Actin, held in Troy, New York, August 5-9, 1992

During the period August 5-9, 1992, and immediately preceding the 1992 Gordon Research Conference on Motile and Contractile Systems, the "Third International Conference on the Structure and Function of Ubiquitous Cellular Protein Actin" was held at the Emma Willard School in Troy, New York, under the title "ACTIN '92". This conference focused on the fundamental properties and cellular functions of actin and actin­ based microfilament systems. The first conference in this series was held in 1982, in Sydney, Australia, and hosted by Dr. Cristobal G. dos Remedios and Dr. Julian A. Barden, both from the University of Sydney (New South Wales, Austrailia). The second conference convened in Monza, Italy in June 1987, and was organized by Dr. Roberto Colombo, University of Milan (Italy). This third gathering of researchers devoted to the study of actin and actin-associated proteins was organized by Dr. James E. Estes, Albany Stratton V A Medical Center and Dr. Paul 1. Higgins, Albany Medical College, who were assisted by an Organizing Committee consisting of Dr. Edward D. Korn (National Heart, Lung and Blood Institute, NIH), Dr. Thomas P. Stossel (Massachusetts General Hospital), Dr. Fumio Matsumura (Rutgers University), and Dr. Stephen Farmer (Boston University). This meeting was dedicated to the many pioneering contributions of Professor Fumio Oosawa to the field of actin research. Front Matter....Pages i-viii Front Matter....Pages 1-1 Vibrational Modes of G-Actin....Pages 3-12 Combining Electron Microscopy and X-Ray Crystallography Data to Study the Structure of F-Actin and its Implications for Thin-Filament Regulation In Muscle....Pages 13-23 Evidence for an F-Actin Like Conformation in the ACTIN:DNASE I Complex....Pages 25-34 Actin-Bound Nucleotide/Divalent Cation Interactions....Pages 35-49 Influence of the High Affinity Divalent Cation on Actin Tryptophan Fluorescence....Pages 51-57 C-Terminus on Acitn: Spectroscopic and Immunochemical Examination of its Role in Actomyosin Interactions....Pages 59-70 Actin Polymerization: Regulation by Divalent Metal Ion and Nucleotide Binding, ATP Hydrolysis and Binding of Myosin....Pages 71-81 Front Matter....Pages 83-83 Structural Requirements of Tropomyosin for Binding to Filamentous Actin....Pages 85-96 Actin-Gelsolin Interaction....Pages 97-104 Actin Regulation and Surface Catalysis....Pages 105-112 Caldesmon: Possible Functions in Microfilament Reorganization During Mitosis and Cell Transformation....Pages 113-122 Cytoskeleton, Motile Structures and Macromolecular Crowding....Pages 123-130 Front Matter....Pages 131-131 Actin Filament Dynamics in Cell Motility....Pages 133-145 Changes in Adhesion Plaque Protein Levels Regulate Cell Motility And Tumorigenicity....Pages 147-157 Induction of Collagen Synthesis in Response to Adhesion and TGFβ is Dependent on the Actin-Containing Cytoskeleton....Pages 159-168 Gelsolin Expression in Normal Human Keratinocytes is a Function of Induced Differentiation....Pages 169-181 Actin Filaments and the Spatial Positioning of mRNAS....Pages 183-189 Redistribution of p52(PAI-1) mRNA to the Cytoskeletal Framework Accompanies Increased p52(PAI-1) Expression in Cytochalasin D-Stimulated Rat Kidney Cells....Pages 191-203 Brush Border Myosin I Has A Calmodulin/Phosphatidylserine Switch and Tail Actin-Binding....Pages 205-213 Control of p52(PAI-1) Gene Expression in Normal and Transformed Rat Kidney Cells: Relationship between p52(PAI-1) Induction and Actin Cytoarchitecture....Pages 215-230 Back Matter....Pages 231-236