A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. The A~3~ receptor is increasingly being recognized for its biological roles throughout the body, and many A~3~ receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: * A3 Adenosine Receptor signal transduction * Adenosine Receptor medicinal chemistry * Effects and therapeutic applications of Adenosine Receptors on tissues and organs * Adenosine Receptors and inflammatory and auto-immune diseases * Adenosine Receptors and cancer The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike. Front Matter....Pages i-xv Front Matter....Pages 1-1 From Hypertension (+) to Asthma: Interactions with the Adenosine A 3 Receptor from a Personal Perspective....Pages 3-26 Front Matter....Pages 28-28 Thermodynamic Analysis in Drug–Receptor Binding: The A 3 Adenosine Receptor....Pages 29-48 Pharmacology and Molecular Biology of A 3 Adenosine Receptors....Pages 49-58 Front Matter....Pages 60-60 Regulation of Second Messenger Systems and Intracellular Pathways....Pages 61-73 The Desensitisation as A 3 Adenosine Receptor Regulation: Physiopathological Implications....Pages 75-90 Front Matter....Pages 92-92 A 3 Adenosine Receptor Agonists: History and Future Perspectives....Pages 93-120 A 3 Adenosine Receptor Antagonists: History and Future Perspectives....Pages 121-147 Molecular Modeling and Reengineering of A 3 Adenosine Receptors....Pages 149-161 Front Matter....Pages 164-164 Adenosine A 3 Receptor Signaling in the Central Nervous System....Pages 165-188 Cardiovascular Biology of the A 3 Adenosine Receptor....Pages 189-208 A 3 Adenosine Receptor in the Pulmonary System....Pages 209-233 A 3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation....Pages 235-256 Adenosine A 3 Receptors in Muscle Protection....Pages 257-280 A 3 Adenosine Receptors, HIF-1 Modulation and Atherosclerosis....Pages 281-288 Front Matter....Pages 290-290 Rheumatoid Arthritis: History, Molecular Mechanisms and Therapeutic Applications....Pages 291-298 Front Matter....Pages 300-300 Agonists and Antagonists: Molecular Mechanisms and Therapeutic Applications....Pages 301-317 Back Matter....Pages 319-322 This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make “A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics” an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3). This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. The A 3 receptor is increasingly being recognized for its biological roles throughout the body, and many A 3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction Adenosine Receptor medicinal chemistry Effects and therapeutic applications of Adenosine Receptors on tissues and organs Adenosine Receptors and inflammatory and auto-immune diseases Adenosine Receptors and cancer The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.