A Textbook of Clinical Pharmacology and Therapeutics, 5th edition

If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding. Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, 'personalized medicine', gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative medicines and nutraceuticals has been introduced and Further Reading lists have been updated to include key medical websites. All medical students and junior doctors who read this book will learn not only how to use drugs safely and effectively, but, importantly, the rationale behind effective prescribing decisions. Book title 4 CONTENTS 8 FOREWORD 9 PREFACE 10 ACKNOWLEDGEMENTS 11 PART I: GENERAL PRINCIPLES 12 1 Introduction to therapeutics 14 2 Mechanisms of drug action (pharmacodynamics) 17 3 Pharmacokinetics 22 4 Drug absorption and routes of administration 28 5 Drug metabolism 35 6 Renal excretion of drugs 42 7 Effects of disease on drug disposition 45 8 Therapeutic drug monitoring 52 9 Drugs in pregnancy 56 10 Drugs in infants and children 63 11 Drugs in the elderly 67 12 Adverse drug reactions 73 13 Drug interactions 82 14 Pharmacogenetics 90 15 Introduction of new drugs and clinical trials 97 16 Cell-based and recombinant DNA therapies 103 17 Alternative medicines: herbals and nutraceuticals 108 PART II: THE NERVOUS SYSTEM 114 18 Hypnotics and anxiolytics 116 19 Schizophrenia and behavioural emergencies 121 20 Mood disorders 127 21 Movement disorders and degenerative CNS disease 135 22 Anti-epileptics 144 23 Migraine 153 24 Anaesthetics and muscle relaxants 156 25 Analgesics and the control of pain 166 PART III: THE MUSCULOSKELETAL SYSTEM 176 26 Anti-inflammatory drugs and the treatment of arthritis 178 PART IV: THE CARDIOVASCULAR SYSTEM 186 27 Prevention of atheroma: lowering plasma cholesterol and other approaches 188 28 Hypertension 196 29 Ischaemic heart disease 207 30 Anticoagulants and antiplatelet drugs 215 31 Heart failure 222 32 Cardiac dysrhythmias 228 PART V: THE RESPIRATORY SYSTEM 242 33 Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders 244 PART VI: THE ALIMENTARY SYSTEM 256 34 Alimentary system and liver 258 35 Vitamins and trace elements 276 PART VII: FLUIDS AND ELECTROLYTES 282 36 Nephrological and related aspects 284 PART VIII: THE ENDOCRINE SYSTEM 294 37 Diabetes mellitus 296 38 Thyroid 303 39 Calcium metabolism 308 40 Adrenal hormones 313 41 Reproductive endocrinology 318 42 The pituitary hormones and related drugs 327 PART IX: SELECTIVE TOXICITY 332 43 Antibacterial drugs 334 44 Mycobacterial infections 345 45 Fungal and non-HIV viral infections 351 46 HIV and AIDS 362 47 Malaria and other parasitic infections 372 48 Cancer chemotherapy 378 PART X: HAEMATOLOGY 398 49 Anaemia and other haematological disorders 400 PART XI: IMMUNOPHARMACOLOGY 408 50 Clinical immunopharmacology 410 PART XII: THE SKIN 420 51 Drugs and the skin 422 PART XIII: THE EYE 432 52 Drugs and the eye 434 PART XIV: CLINICAL TOXICOLOGY 442 53 Drugs and alcohol abuse 444 54 Drug overdose and poisoning 455 INDEX 462 A 462 B 464 C 464 D 466 E 467 F 467 G 468 H 468 I 469 J 470 K 470 L 470 M 470 N 471 O 472 P 472 Q 474 R 474 S 474 T 475 U 476 V 476 W 476 X 476 Y 476 Z 476 9780340900468 Fully revised throughout and extensively illustrated, this edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another A comprehensive textbook of clinical pharmacology - all medical students and trainee doctors who read this book will know how to use drugs safely and to make prescribing decisions effectively.