A Textbook of Clinical Pharmacology and Therapeutics, 5Ed (A Hodder Arnold Publication)

If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding. Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, personalized medicine, gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative medicines and nutraceuticals has been introduced and Further Reading lists have been updated to include key medical websites. All medical students and junior doctors who read this book will learn not only how to use drugs safely and effectively, but, importantly, the rationale behind effective prescribing decisions. Book title......Page 4 CONTENTS......Page 8 FOREWORD......Page 9 PREFACE......Page 10 ACKNOWLEDGEMENTS......Page 11 PART I: GENERAL PRINCIPLES......Page 12 1 Introduction to therapeutics......Page 14 2 Mechanisms of drug action (pharmacodynamics)......Page 17 3 Pharmacokinetics......Page 22 4 Drug absorption and routes of administration......Page 28 5 Drug metabolism......Page 35 6 Renal excretion of drugs......Page 42 7 Effects of disease on drug disposition......Page 45 8 Therapeutic drug monitoring......Page 52 9 Drugs in pregnancy......Page 56 10 Drugs in infants and children......Page 63 11 Drugs in the elderly......Page 67 12 Adverse drug reactions......Page 73 13 Drug interactions......Page 82 14 Pharmacogenetics......Page 90 15 Introduction of new drugs and clinical trials......Page 97 16 Cell-based and recombinant DNA therapies......Page 103 17 Alternative medicines: herbals and nutraceuticals......Page 108 PART II: THE NERVOUS SYSTEM......Page 114 18 Hypnotics and anxiolytics......Page 116 19 Schizophrenia and behavioural emergencies......Page 121 20 Mood disorders......Page 127 21 Movement disorders and degenerative CNS disease......Page 135 22 Anti-epileptics......Page 144 23 Migraine......Page 153 24 Anaesthetics and muscle relaxants......Page 156 25 Analgesics and the control of pain......Page 166 PART III: THE MUSCULOSKELETAL SYSTEM......Page 176 26 Anti-inflammatory drugs and the treatment of arthritis......Page 178 PART IV: THE CARDIOVASCULAR SYSTEM......Page 186 27 Prevention of atheroma: lowering plasma cholesterol and other approaches......Page 188 28 Hypertension......Page 196 29 Ischaemic heart disease......Page 207 30 Anticoagulants and antiplatelet drugs......Page 215 31 Heart failure......Page 222 32 Cardiac dysrhythmias......Page 228 PART V: THE RESPIRATORY SYSTEM......Page 242 33 Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders......Page 244 PART VI: THE ALIMENTARY SYSTEM......Page 256 34 Alimentary system and liver......Page 258 35 Vitamins and trace elements......Page 276 PART VII: FLUIDS AND ELECTROLYTES......Page 282 36 Nephrological and related aspects......Page 284 PART VIII: THE ENDOCRINE SYSTEM......Page 294 37 Diabetes mellitus......Page 296 38 Thyroid......Page 303 39 Calcium metabolism......Page 308 40 Adrenal hormones......Page 313 41 Reproductive endocrinology......Page 318 42 The pituitary hormones and related drugs......Page 327 PART IX: SELECTIVE TOXICITY......Page 332 43 Antibacterial drugs......Page 334 44 Mycobacterial infections......Page 345 45 Fungal and non-HIV viral infections......Page 351 46 HIV and AIDS......Page 362 47 Malaria and other parasitic infections......Page 372 48 Cancer chemotherapy......Page 378 PART X: HAEMATOLOGY......Page 398 49 Anaemia and other haematological disorders......Page 400 PART XI: IMMUNOPHARMACOLOGY......Page 408 50 Clinical immunopharmacology......Page 410 PART XII: THE SKIN......Page 420 51 Drugs and the skin......Page 422 PART XIII: THE EYE......Page 432 52 Drugs and the eye......Page 434 PART XIV: CLINICAL TOXICOLOGY......Page 442 53 Drugs and alcohol abuse......Page 444 54 Drug overdose and poisoning......Page 455 A......Page 462 C......Page 464 D......Page 466 F......Page 467 H......Page 468 I......Page 469 M......Page 470 N......Page 471 P......Page 472 S......Page 474 T......Page 475 Z......Page 476 Fully revised throughout and extensively illustrated, this edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another A comprehensive textbook of clinical pharmacology - all medical students and trainee doctors who read this book will know how to use drugs safely and to make prescribing decisions effectively.