A Short Guide to Clinical Pharmacokinetics (Sep 24, 2024)_(981974282X)_(Springer).pdf

This book is a complete resource on pharmacokinetics, pharmacodynamics and pharmacogenomics in clinical practice. It consists of seven chapters that cover various aspects of pharmacokinetics and its clinical applications. The chapters are structured to provide clear objectives and keywords are bolded throughout the text to facilitate understanding. The topics covered include the significance of pharmacokinetics in clinical practice, factors affecting pharmacokinetic parameters, pharmacokinetic drug interactions, therapeutic drug monitoring, dosage adjustment in different population groups, the influence of hepatic diseases on pharmacokinetics and the impact of pharmacogenomics on pharmacokinetics and pharmacodynamics. The book is written in simple language to make the concepts accessible to all readers. This book is a comprehensive resource for students pursuing a doctoral degree in pharmacy, as well as academicians and researchers in clinical pharmacokinetics. Foreword Preface Acknowledgements Contents Editors and Contributors About the Editors Contributors Abbreviations 1: Introduction to Clinical Pharmacokinetics 1.1 Introduction 1.2 Overview of Clinical Pharmacokinetics (Leary and Williams 2016) 1.3 Pharmacokinetic Factors Determining Ideal Therapeutics One-Compartment Model Curves of Concentration Versus Time Zero-Order Elimination First-Order Elimination Drug Clearance (CL) Maintaining a Constant Steady-State Concentration (Cpss) Determination of CL Volume of Distribution (Vd) Vd and Clinical PK Half-Life (t1/2) Time-Course of Drug Elimination and Accumulation Correlation Between Vd, CL, and t1/2 Oral Availability (F) Protein Binding (PB) pH and Pharmacokinetics Drug Absorption from the Stomach Drug Elimination in the Kidney Drug Delivery into Third Spaces Relationship Between Pharmacokinetics and Effect Kinetics 1.4 Pharmacokinetic Parameters Permeability Bioavailability (F) P-Glycoprotein (PGP) Volume