A Prescription for Change: The Looming Crisis in Drug Development (The Luther H. Hodges Jr. and Luther H. Hodges Sr. Series on Business, Entrepreneurship, and Public Policy)

The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, __A Prescription for Change__ reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come. The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes -- and indeed because of them -- our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come. - Publisher. Annotation The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy.To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come The Introduction Of New Medicines Has Dramatically Improved The Quantity And Quality Of Individual And Public Health While Contributing Trillions Of Dollars To The Global Economy. In Spite Of These Past Successes--and Indeed Because Of Them--our Ability To Deliver New Medicines May Be Quickly Coming To An End. Moving From The Twentieth Century To The Present, This Book Reveals How Changing Business Strategies Combined With Scientific Hubris Have Altered The Way New Medicines Are Discovered, With Dire Implications For Both Health And The Economy. To Explain How We Have Arrived At This Pivotal Moment, Michael Kinch Recounts The History Of Pharmaceutical And Biotechnological Advances In The Twentieth Century. Kinch Relates Stories Of The Individuals And Organizations That Built The Modern Infrastructure That Supports The Development Of Innovative New Medicines. He Shows That An Accelerating Cycle Of Acquisition And Downsizing Is Cannibalizing That Infrastructure Kinch Demonstrates The Dismantling Of The Pharmaceutical And Biotechnological Research And Development Enterprises Could Also Provide Opportunities To Innovate New Models That Sustain And Expand The Introduction Of Newer And Better Breakthrough Medicines In The Years To Come. Cover ......Page 1 Contents......Page 8 Acknowledgments......Page 10 Introduction: How Did We Reach This Point?......Page 16 Chapter One: Why Regulate Medicines? ......Page 33 Chapter Two: Trials and Tribulations ......Page 50 Chapter Three: Dreams of Greatness: The Birth of the Pharmaceutical Industry......Page 68 Chapter Four: Triumph and Tragedy ......Page 91 Chapter Five: Ivory Tower of Power ......Page 113 Chapter Six: The DNA of Biotechnology ......Page 135 Chapter Seven: Blockbusters and Bombs: Pressures on the Pharmaceutical Industry ......Page 155 Chapter Eight: Sea Monsters, Immunauts, and Death Panels ......Page 178 Chapter Nine: Drama on the I-270 Tech Corridor ......Page 200 Chapter Ten: Autophagy ......Page 221 Chapter Eleven: Three Views of a Train Wreck ......Page 241 Chapter Twelve: Bridging the Valley ......Page 267 Notes......Page 288 B......Page 348 F......Page 349 J......Page 350 N......Page 351 S ......Page 352 V ......Page 353 Z ......Page 354 "The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the twentieth century to the present, this book reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy"-- Provided by publisher