A metabolomic study of biomarkers of meat and fish intake ,

Meat and fish intakes have been associated with various chronic diseases. The use of specific biomarkers may help to assess meat and fish intake and improve subject classification according to the amount and type of meat or fish consumed. A metabolomic approach was applied to search for biomarkers of meat and fish intake in a dietary intervention study and in free-living subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In the dietary intervention study, 4 groups of 10 subjects consumed increasing quantities of chicken, red meat, processed meat, and fish over 3 successive weeks. Twenty-four-hour urine samples were collected during each period and analyzed by high-resolution liquid chromatography-mass spectrometry. Signals characteristic of meat or fish intake were replicated in 50 EPIC subjects for whom a 24-h urine sample and 24-h dietary recall were available and who were selected for their exclusive intake or no intake of any of the 4 same foods. A total of 249 mass spectrometric features showed a positive dose-dependent response to meat or fish intake in the intervention study. Eighteen of these features best predicted intake of the 4 food groups in the EPIC urine samples on the basis of partial receiver operator curve analyses with permutation testing (areas under the curve ranging between 0.61 and 1.0). Of these signals, 8 metabolites were identified. Anserine was found to be specific for chicken intake, whereas trimethylamine-oxide showed good specificity for fish. Carnosine and 3 acylcarnitines (acetylcarnitine, propionylcarnitine, and 2-methylbutyrylcarnitine) appeared to be more generic indicators of meat and meat and fish intake, respectively. The meat and fish biomarkers identified in this work may be used to study associations between meat and fish intake and disease risk in epidemiologic studies. This trial was registered at clinicaltrials.gov as NCT01684917. In this second edition of the bestselling title from the acclaimed Nutrition Society Textbook series, Public Health Nutrition has been extensively revised to ensure that it reflects the latest evidence-based knowledge and research. Ground-breaking and comprehensive in both its scope and approach, Public Health Nutrition has been fully updated by an expert editorial team to cover the most recent changes in the field. It now offers a structured overview of the subjects core concepts and considers public health nutrition tools and the application of intervention strategies. Divided into five key sections, Public Health Nutrition contains a wealth of information, With a clear and concise structure, Public Health Nutrition is an essential purchase for students of nutrition, dietetics and other healthcare areas, as well as an invaluable practical guide for health professionals working within public health. A supporting companion website featuring multiple-choice, short answer, and essay style questions is available at In This Second Edition Of The Bestselling Title From The Acclaimed Nutrition Society Textbook Series, Public Health Nutrition Has Been Extensively Revised To Ensure That It Reflects The Latest Evidence?based Knowledge And Research. Ground?breaking And Comprehensive In Both Its Scope And Approach, Public Health Nutrition Has Been Fully Updated By An Expert Editorial Team To Cover The Most Recent Changes In The Field. It Now Offers A Structured Overview Of The Subject S Core Concepts And Considers Public Health Nutrition Tools And The Application Of Intervention Strategies. -- Back Cover. Edited On Behalf Of The Nutrition Society By Judith L. Buttriss, Ailsa A. Welch, John M. Kearney, Susan A. Lanham-new. Includes Bibliographical References And Index. "Divided into five key sections, Public health nutrition contains a wealth of information, including : public health nutrition concepts and assessment tools, and their application in light of the latest evidence ; case studies to illustrate how best to apply the theory and evidence to policy and practice ; an examination of nutrition throughout the lifecycle, and the relationship between diet and disease, including in relation to obesity, diabetes, cancer, as well as mental health ; the impact of environmental factors on public health ; public health strategies, policies and approaches."--Page 4 de la couverture