A Handbook for DNA-Encoded Chemistry : Theory and Applications for Exploring Chemical Space and Drug Discovery

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: * Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry * Helps chemists generate and screen novel chemical libraries of large size and quality * Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry * Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery * Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods Just Enough Knowledge? -- A Brief History Of The Development Of Combinatorial Chemistry And The Emerging Need For Dna-encoded Chemistry -- A History Of Dna-encoding -- Dna-compatible Chemistry -- Foundations Of A Dna-encoded Library (del) -- Practices For Synthesizing Dna-encoded Libraries -- Chemical Gene Design For Dna-encoded Libraries -- Analytical Challenges For Dna-encoded Library Systems -- Information Technology: Functionality And Architectures For Dna-encoding -- Theoretical Considerations Of The Application Of Dna-encoded Libraries To Drug Discovery -- Begin With The End In Mind : The Hit-to-lead Process -- Enumeration And Visualization Of Large Combinatorial Chemical Libraries -- Screening Large Compound Collections -- Reported Applications Of Dna-encoded Library Chemistry -- Dual-pharmacophore Dna-encoded Chemical Libraries -- Hit Identification And Hit Follow-up -- Using Dna To Program Chemical Synthesis, Discover New Reactions, And Detect Ligand Binding -- An Outlook And The Changing Feasibility And Economics Of Chemical Diversity Exploration With Dna-encoded Combinatorial Approaches -- Keeping The Promise? An Outlook On Dna Chemical Library Technology. Edited By Robert A. Goodnow, Jr. Includes Bibliographical References And Index.