5-HT2C Receptors in the Pathophysiology of CNS Disease (The Receptors Book 22)

Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, “The Receptors,” The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors’ therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor. Front Matter....Pages i-xi The Making of the 5-HT 2C Receptor....Pages 1-16 Serotonin 5-HT 2C Receptors: Chemical Neuronatomy in the Mammalian Brain....Pages 17-27 The Medicinal Chemistry of 5-HT 2C Receptor Ligands....Pages 29-50 Insights into 5-HT 2C Receptor Function Gained from Transgenic Mouse Models....Pages 51-73 Serotonin 5-HT 2C Receptor Signal Transduction....Pages 75-96 Homology Modeling of 5-HT 2C Receptors....Pages 97-127 5-HT 2C Receptor Dimerization....Pages 129-155 RNA Editing of 5-HT 2C Receptor and Neuropsychiatric Diseases....Pages 157-167 Serotonergic Control of Adult Neurogenesis: Focus on 5-HT 2C Receptors....Pages 169-185 The Constitutive Activity of 5-HT 2C Receptors as an Additional Modality of Interaction of the Serotonergic System....Pages 187-213 The 5-HT 2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies....Pages 215-247 The Role of 5-HT 2C Receptors in the Pathophysiology and Treatment of Depression....Pages 249-260 5-HT 2C Receptors and Suicidal Behavior....Pages 261-274 The 5-HT 2C Receptor as a Target for Schizophrenia....Pages 275-291 Serotonin and Reward-Related Behavior: Focus on 5-HT 2C Receptors....Pages 293-324 Tat-3L4F: A Novel Peptide for Treating Drug Addiction by Disrupting Interaction Between PTEN and 5-HT 2C Receptor....Pages 325-337 The Role of Serotonin in Eating Behavior: Focus on 5-HT 2C Receptors....Pages 339-350 Physiological and Pathophysiological Aspects of 5-HT 2c Receptors in Basal Ganglia....Pages 351-382 Modeling Tardive Dyskinesia: Predictive 5-HT 2C Receptor Antagonist Treatment....Pages 383-392 The Role of 5-HT 2A/2C Receptors in Sleep and Waking....Pages 393-412 Role of Alternative Splicing of the 5-HT 2C Receptor in the Prader–Willi Syndrome....Pages 413-427 The Role of 5-HT 2C Receptor in Epilepsy....Pages 429-444 The Role of Serotonin on Attentional Processes and Executive Functioning: Focus on 5-HT 2C Receptors....Pages 445-460 5-HT 2C Receptors in Learning....Pages 461-507 The Role of 5-HT 2C Polymorphisms in Behavioral and Psychological Symptoms of Alzheimer Disease....Pages 509-521 Ocular Hypotension: Involvement of Serotonergic 5-HT 2 Receptors....Pages 523-543 Back Matter....Pages 545-557 Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.