37th Hemophilia Symposium Hamburg 2006 : Epidemiology;Treatment of Inhibitors in Hemophiliacs; Hemophilic Arthropathy and Synovitis; Relevant Hemophilia Treatment 2006; Pediatric Hemostasiology; Free Lectures

This book contains the contribution to the 37th Hemophilia Symposium, Hamburg 2006. The main topics are epidemiolgy, treatment of inhibitors in hemophiliacs, hemophilic arthropathy and synovitis, relevant hemophilia treatment 2006, and pediatric hemostasiology. The volume is rounded off by numerous free papers and posters on hemophilia, casuistics, and diagnostics. Front Matter....Pages I-XXXIV Johann Lukas Schoenlein Prize 2006....Pages 1-2 Front Matter....Pages 3-3 HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2005/2006 Survey)....Pages 5-16 Hemophilia Registry of the Medical Committee of the Swiss Hemophilia Association — Update and Annual Survey 2006....Pages 17-21 Front Matter....Pages 23-23 Detection of Factor VIII-Specific Memory B Cells in Patients with Hemophilia A and Factor VIII Inhibitors....Pages 25-36 Novel Strategies for FVIII: Half-life Prolongation....Pages 37-37 Front Matter....Pages 39-39 Predictive Parameters of Fitness in Hemophiliac Children....Pages 41-44 Hemophilia and Exercise Project (HEP) Conception and Contents of a “Programmed Sports Therapy” for Hemophilic Patients....Pages 45-59 Results of German Hemophiliacs Self-Assessment of Health and Social Status: With Emphasis on Orthopedic Function....Pages 60-63 Front Matter....Pages 65-65 Developing a German Hemophilia Register....Pages 67-67 Front Matter....Pages 69-69 Thrombin Generation in Children with Hemophilia and VWD — Comparing a Fluorimetric Method and ROTEM....Pages 71-74 Thrombin Generation in Severely Obese Children....Pages 75-80 Protein C Promoter Genotypes Associate with Susceptibility, Development of Sepsis, and Lower Blood Pressure in Young Children with Systemic Meningococcemia....Pages 81-87 Life of Teenage Hemophiliacs....Pages 88-91 Front Matter....Pages 93-93 Monocytes Enhance rVIIa Induced Thrombin Generation in Absence of Platelets and Microparticles....Pages 95-105 Mutation Detection Rate in Female Patients with Reduced Factor VIII Activity and Negative Family History for Hemophilia A....Pages 106-108 Investigation of Underlying Reasons of Factor VIII Deficiency in Hemophilia A Patients with Undetectable Mutations in the F8 Gene....Pages 109-113 Monitoring of Antiplatelet Therapy Using Whole Blood Aggregometry: Experiences and Approaches to Dose Adaptation....Pages 114-115 Front Matter....Pages 117-117 No Complications in Switching from Recombinate to Advate — a Prospective Surveillance in 22 Children....Pages 119-121 Epidemiology and Treatment of Hemophilia A, B and von Willebrand Disease of Type 3 in the Eastern Part of German....Pages 122-124 Database Management System for a Hemophilia Comprehensive Care Center....Pages 125-126 Front Matter....Pages 117-117 Hepatocellular Carcinoma in Patients with Hemophilia and Chronic Hepatitis C Infection....Pages 127-129 Elucidation of Gross Genomic Rearrangements Involving Large Deletions in the Clotting Factor VIII Gene....Pages 130-137 The Centro American Hemophilia Registry, of the CARS Hemophilia Group — Update September 2006....Pages 138-141 Two Examples of the Influence of Psychological Stress on the von Willebrand Factor Activity....Pages 142-144 Efficacy of Chronic Hepatitis C Treatment in Hemophilic Patients During the Last 10 Years: a Single Center Experience....Pages 145-148 Dynamic of Thrombin Generation in Patients with Severe Hemophilia A....Pages 149-151 Hemophilia and Exercise Project (HEP): Effects of a Two-Year Sports Therapy on Physical Activity Behavior and Bleeding Frequency by Persons with Hemophilia....Pages 152-152 Hemophilia Summer Camp in Germany, 1996–2005....Pages 153-153 Impact of Hemophilia on the Psychological Health of Hemophilia Patients in Romania....Pages 154-159 Starter-Kit for Patients Suffering from Hemophilia — A Project Initiated by the German Hemophilia Assistant Committee....Pages 160-162 Documentation in Hemophilia Treatment....Pages 163-164 Short-time Prophylaxis with FEIBA in Three Patients with Hemophilia A and High Titer Inhibitors....Pages 165-167 Successful Treatment of a Patient with High Titer Acquired Factor VIII Inhibitor (114 BU) with Rituximab....Pages 171-173 Preoperative Arterial Embolization of a Hemophilic Pseudo Tumor before Osteosynthesis in a Patient with Hemophilia A and Pathological Femoral Fracture....Pages 174-177 Successful Liver Transplantation in Two Patients with Severe Hemophilia A....Pages 178-180 Out from the Cold: Severe Erythema and Clumped Red Cells....Pages 181-183 Acquired Glanzmann Thrombasthenia in a Patient with Myelodysplastic Syndrome....Pages 184-186 Case Report of an Acquired Inhibitor Against Factor XIII....Pages 187-189 Elbow Endoprosthesis in Hemophilic Arthropathy....Pages 190-192 Pseudohomozygous APC Resistance Report on Two Patients and a Novel Mutation in the Factor V Gene....Pages 193-197 Front Matter....Pages 117-117 Pseudo-Homozygous APC Resistance Due to Coinheritance of Heterozygous Factor V — R506Q and Type I Deficiency Associated with Thrombosis....Pages 198-200 Three Cases of In-stent Thrombosis in Patients with Clopidogrel Non-response....Pages 201-201 Thrombin Generation in Pregnancy....Pages 205-211 Thrombin Generation — Comparison of ROTEM and Technothrombin TGA....Pages 212-216 Multiple Electrode Aggregometry in Patients on Chronic Aspirin and/or Clopidogrel Treatment....Pages 217-217 Endogenous Thrombin Potential in Women with Recurrent Miscarriage and/or Repeated In-Vitro-Fertilization Failure....Pages 218-220 One Year TTP Diagnosis in the Central Laboratory of the University of Mainz....Pages 221-225 Venous Thromboembolism — A Metabolic Disease?....Pages 229-230 Structural Investigation of Two Novel Mutations in Coagulation Factor V by Molecular Modeling....Pages 231-233 High Levels of Human Factor IX Transgene Expression in Mice Increase Blood Procoagulant Activity....Pages 234-237 Factor VII Deficiency: Clinical Manifestation and Molecular Genetics of 718 Subjects with FVII Gene Mutations....Pages 238-246 Therapeutical Options for Congenital FVII Deficiency — The HK 7 Project of the International Greifswald Registry of the Congenital FVII Deficiency (GR-HK-7)....Pages 247-251 Characterization of a Mutation in Exon 1 of the FVII Gene — a Case of RNA Editing?....Pages 252-255 Analysis of the Biological Importance of the VKORC1 Gene via Knock-Out Mice....Pages 256-258 In Vivo-Assay for Warfarin-Resistance by Coexpression of VKORC1 and Vitamin K-Dependent Coagulation Factors....Pages 259-260 Functional Promoter Polymorphism in the VKORC1 Gene is no Major Genetic Determinant for Vitamin K Dependent Coagulation Factor Activity....Pages 261-263 Influence of VKORC1 Haplotypes on Cardiovascular Disease....Pages 264-265 Creation and Characterization of a Knock-Out Mouse for the VKORC1L1 -Gene....Pages 266-268 Novel Variants in VKORC1 — the Target Protein of Cumarin-Type Anticoagulants — in Rodents from Warfarin-Resistance Areas in Europe, Asia and America....Pages 269-270 Recombinant Expression and 3D-Modelling of C1-Inhibitor Mutants....Pages 271-272 Front Matter....Pages 117-117 Five Novel Mutations in F13B Gene Resulting in Mild FXIII Deficiency....Pages 273-274 Idiopathic Thrombocytopenic Purpura in Children: Predictive Factors for the Outcome....Pages 275-279 Preoperative DDAVP-Testing in Patients with von Willebrand Disease....Pages 280-282 Back Matter....Pages 283-286 Editors: I. Scharrer, W. Schramm ; Scientific Board, I. Scharrer, W. Schramm ; Chairmen, R. Seitz ... [et Al.]. Presentation: Epidemiology, Treatment Of Inhibitors In Hemophiliacs, Hemophilic Arthropathy And Synovitis, Relavant Hemophilia Treatment 2006, Pediatric Hemostasiololgy, Free Lectures. Includes Bibliographical References And Index.