30th hemophilia symposium : Hamburg 1999 ; presentation: HIV infection and epidemiology in hemophilia, gene therapy in Hemophilia A and B, therapy of Hepatitis C, inhibitors in hemophilia, long-term results after joint replacement, pediatric hemostasiolog

Front Matter....Pages I-XXXIV Front Matter....Pages 1-1 Causes of Death and AIDS-Related Disease in Hemophilia Patients in Germany (Inquiries 1999)....Pages 3-10 Front Matter....Pages 11-11 Genotype-Phenotype Correlation in Hemophilia A....Pages 13-21 Front Matter....Pages 23-23 Current Therapy of Hepatitis C Virus Infection....Pages 25-31 Interferon Alpha-2a Treatment in Patients with Hepatitis C and Bleeding Disorders....Pages 32-34 Report on Experience in the Treatment of Hepatitis C in HIV-Coinfected Hemophiliacs....Pages 35-41 Front Matter....Pages 43-43 A New Therapeutic Option for Inhibitor Elimination in Patients with Acquired Hemophilia....Pages 45-52 Front Matter....Pages 53-53 Long-Term Results After Total Knee and Total Hip Replacement in Hemophilic Arthropathy....Pages 55-61 Total Knee Prosthesis in Hemophiliacs with Multilocular Hemophilic Arthropathy — The Zurich Experience....Pages 62-64 Corrective Osteotomy of the Lower Extremity in Hemophilic Arthropathy of the Knee and Hip Joint....Pages 65-70 Front Matter....Pages 71-71 Anticoagulant Action of Activated Protein C is Diminished by Alpha 2 -Macroglobulin in Newborn Plasma....Pages 73-85 Functional Consequences of Differences in Carbohydrate Sequences of Fetal and Adult Plasminogen and Fibrinogen....Pages 86-101 Hereditary Thrombophilic Risk Profiles in Children with Spontaneous Venous Thromboembolism....Pages 102-109 Inhibitor Development in Previously Untreated Patients with Hemophilia A and B: A Prospective 23-Year Follow-Up....Pages 110-113 HIT Type II without Thrombocytopenia in a 15-Year-Old Boy with Protein S Deficiency and Recurrent Deep Vein Thrombosis....Pages 114-116 Front Matter....Pages 117-117 Modified Bonn-Malmö Protocol....Pages 119-125 A Novel Type of Mutation at the Propeptide Cleavage Site (Ala+1Thr) Causing Symptomatic Protein C Type II Deficiency....Pages 126-131 Lithuanian Hemophilia A and B Register Comprising Phenotypic and Genotypic Data....Pages 132-143 Greifswald Hemophilia B Study....Pages 144-153 Successful Treatment of Patients with von Willebrand Disease Using a High-Purity Double Virus Inactivated FVIII/vWF Concentrate (IMMUNATE)....Pages 154-160 Front Matter....Pages 161-161 Industry Sponsoring and Acceptance of Benefit by Hospital Officials: Opportunities and Limits of Third-Party Funding....Pages 163-175 Front Matter....Pages 177-177 Experience with Recombinant Factor IX (Benefix) in Pediatrics....Pages 179-181 Articular Cartilage Is More Susceptible to Blood-Induced Damage in Young Than in Old Age....Pages 182-186 Chronic Liver Disease in Hemophilia Patients....Pages 187-190 Human Immunodeficiency Virus-Negative ››High-Risk Patients‹‹ with Hemophilia or Severe von Willebrand Disease Type 3: Coincidence or Genetics?....Pages 191-193 Quality Management and Economic Aspects in Hemotherapy in the Federal Republic of Germany: Description of a Retrospective Cross-Sectional Multicenter Trial....Pages 194-196 How Hemophiliacs View the Services Offered by ››Bluter Betreuung Bayern e.V.‹‹ Results of a Survey Carried Out for the Association’s Tenth Anniversary....Pages 197-198 Alpha Tocopherol — A Medication with Few Side Effects for Treating Pain in Patients with Hemarthrosis....Pages 199-201 Neurosensorial Sequelae in Hemophilia....Pages 202-206 Front Matter....Pages 207-207 Effect of Vitamin Supplementation in Venous Thrombosis Patients with Hyperhomocysteinemia....Pages 209-213 Therapy and Prophylaxis of the Thromboembolic Syndrome in Pregnancy and Post Delivery....Pages 214-216 Is Factor V Leiden Associated with an Increased Risk for Fetal Loss?....Pages 217-221 Front Matter....Pages 223-223 Congenital Deficiency of Vitamin K Dependent Coagulation Factors in Two Families: Evidence for a Defective Vitamin K-Epoxide-Reductase Complex....Pages 225-234 Twenty-Two Novel Mutations of Factor VII Gene in Factor VII Deficiency....Pages 235-239 Prevalence of Common Mutations and Polymorphisms of the Genes of FII, FV, FVII, FXII, FXIII, MTHFR and ACE — Identified As Risk Factors for Venous and Arterial Thrombosis — in Germany and Different Ethnic Groups (Indians, Blacks) of Costa Rica....Pages 240-260 Factor V Variants — FV Leiden, FV R2 Polymorphism (ex 13), FV Ddel Polymorphism (int 16) - Risk Factors for Venous Thrombosis? Results of a Pilot Study....Pages 261-265 Relation Between Prothrombin Mutation 20210 G→A, Prothrombin Time, Factor V Leiden, and Prothrombin Level....Pages 266-269 Localization and Characterization of Mutations Within the Factor VIII Gene in a Cohort of 212 Patients with Hemophilia A....Pages 270-272 Genomic Diagnosis of Hemophilia A in Hungarian Patients....Pages 273-276 Indirect Genomic Diagnosis of Hungarian Hemophilia B Patients....Pages 277-279 Front Matter....Pages 281-281 Relation of Cardiovascular Fitness, Hemostatic and Metabolic Risk Factors for Coronary Heart Disease in Obese Children and Adolescents....Pages 283-291 Front Matter....Pages 281-281 Inverse Correlation Between Thyroid Function and Hemostatic Risk Factors for Coronary Heart Disease in Obese Children and Adolescents....Pages 292-298 Heparin-Induced Thrombocytopenia Type II in Three Children and Anticoagulant Therapy with Org 10172 (Orgaran)....Pages 299-302 Heparin Concentration, Activated Clotting Time, and Markers of Coagulation Activation During Pediatric Heart Catheterization....Pages 303-306 Therapeutic Options in Immune Thrombocytopenic Purpura in Childhood....Pages 307-312 Camps for Children and Young Adults with Hemophilia in Germany, Austria, and Switzerland....Pages 313-316 Clinical Experience with the PFA-100 System in Children and Adolescents....Pages 317-320 Endothelial Activation Markers in Health and Disease — Big Endothelin-1 and Endothelin-1 in Children....Pages 321-330 Front Matter....Pages 331-331 Dramatic Intra-Abdominal Bleeding — First Symptom of Hemophilia B in a Neonate....Pages 333-335 Postoperative Bleeding in a Sufficiently Substituted Patient with Severe Hemophilia A: Successful Therapy with Administration of Recombinant Factor VIIa....Pages 336-341 Continuous Infusion of Recombinant FIX (BeneFIX) During Herniotomy in an Infant....Pages 342-344 Clinical Course of Intramuscular Bleeds in a Patient with Factor XIII Deficiency....Pages 345-346 Immunthrombocytopenia and Lupus Antibodies in a Patient with Hemophilia A....Pages 347-349 Cerebral Sinus Thrombosis after Asparaginase Therapy....Pages 350-353 Severe Neonatal Thrombosis in a Patient with Factor V Q:506 Mutation and the G20210A Prothrombin Mutation....Pages 354-357 Elevated Lp(a) Level and Heterozygous Factor V Mutation FV 1691 AG in a 26-Year-0ld Female with Ischemic Colitis....Pages 358-360 Acquired Hemophilia in Women Postpartum....Pages 361-362 Front Matter....Pages 363-363 Modulation of Antigens of Neutrophil Granulocytes by Extracorporal Apheresis....Pages 365-368 Glycoprotein IIb/IIIa Receptor Antagonist c7E3 Fab and Anticoagulants Show an Additive Effect on Thrombin-Induced Platelet Aggregation after High Coagulant Challenge in Vitro....Pages 369-377 Between-Drug Comparison of the Effect of Ticlopidine and Acetylsalicylic Acid on Platelets in an In Vitro Circulation Model....Pages 378-379 Rotablation Leads to Significant Platelet Activation: A Flow Cytometric Assessment....Pages 380-381 Front Matter....Pages 363-363 Flow Cytometric Comparison of Platelet Activation During PTCA, Stent Implantation, and Rotablation....Pages 382-383 Analysis of Hemostatic Capacity before and after Extracorporal Platelet-Pheresis by the PFA-100 Test System....Pages 384-387 Heparin Coating of Coronary Stents Increases Time Until Stent Occlusion Due to Delayed Platelet Activation in an In Vitro Circulating Model....Pages 388-389 High-Speed Detection of Human Progenitor Cells (HPC) to Support the Timing of Aphereses....Pages 390-393 Semi-Automated Flow Cytometry Can Help in Timing the Onset of a Stem-Cell Leukapheresis....Pages 394-398 Front Matter....Pages 399-399 Current Topics of Official Batch Release: Determination of FXIII Activity in Fibrin Glues and FXIII Concentrates and Measurement of Heparin/AT Complexes in FVIII Products....Pages 401-407 Comparison of BVDV and SFV Used as Models for Hepatitis C Virus in Virus Validation Studies....Pages 408-416 Preoperative Coagulation Screening in Children Focused on PTT Elevation....Pages 417-419 Resonance Thrombographic Analysis of Coagulation Status after Transfusion of Platelet Concentrates with Different Storage Times....Pages 420-421 Back Matter....Pages 423-427